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InVivo Biosystems Blog

Cultivating hope for STXBP1 epilepsy patients – an inspiring interview with Lior Dor and Sagi Gidali
Alternative Animal Models Unlock Hope in STXBP1 Epilepsy Research
Preclinical Drug Discovery | InVivo Biosystems
Biological Quality Control Assay Validation Services
CRISPR ZEBRAFISH KNOCKIN | InVivo Biosystems
Modeling Anxiety and Stress in Zebrafish: Thigmotaxis
Zebrafish vs. Mouse Models: A New Standard in Behavioral Assays
Rapid Results: The RapidGen™ CRISPR Approach
Using Zebrafish to Combat Cognitive Decline: How a Biopharmaceutical Company Leveraged a Zebrafish Model to characterize a Compound for Neurodegenerative Disease Therapeutics
Speeding up the diagnostic journey for Rare Disease patients: An in vivo discovery platform that helps classify variants of uncertain significance
Whitepaper: What is IND?
Fast, Cost Effective Compound Efficacy Testing using Zebrafish
Better Together? Zebrafish and Mice Models should be utilized in Conjunction.
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A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia [Where are they now: Customer Story]
For Studying Host-Microbe Interactions, Why Choose Zebrafish?
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Leaky Gut Assays in Animal Models
zebrafish as a unique model to research organ regeneration
As a Researcher, Why Choose Zebrafish? Unique Models: Organ Regeneration
No animals, new drugs, no problem
New drugs, No Animals, No Problem. The FDA announced legislative changes – drugs are no longer required to be tested in animals before moving to human trials. What does that mean?
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Zebrafish researchers lack enough tools to efficiently and accurately quantify immune responses. Monoclonal antibodies could change that.
why chose zebrafish as a model
As a Researcher, Why Choose Zebrafish?
WHAM with CRISPR - re-imaging how rare disease therapeutics are developed
Whole-gene Humanized Animal Models (WHAM) with CRISPR – Re-imagining how Rare Disease therapeutics are developed
America is finally investing in Biotechnology & Biomanufacturing in a Big Way
Is our Brain Health Reliant on our Gut?
[Patent Announcement] InVivo Biosystems has officially been issued a patent on WHAM-humanization in the nematode, C. elegans
Looking at Gene Paralogs across both zebrafish and C. elegans Model Organisms [Customer Story]
Healthy Aging and Longevity Research is on the Rise – which is the Best Model Organism to use?
Chemicals Models of Parkinson’s Disease in Larval Zebrafish
Review: How a Small Worm is Helping Uncover the Pathogenicity of Gene Variants
Using Zebrafish as a Model for Opioid Addiction with Dr. Gabriel Bossé (University of Utah)
A Natural Fit – Using Zebrafish to Evaluate Natural Compounds for Anti-Inflammatory Properties
Temperature & C. elegans Part Two: How does Temperature affect development?
Zebrafish 101: A White Paper
C. elegans 101: A White Paper
Does everyone have digestive issues? — Gut dysbiosis is on the rise.
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Models to Research Microbiome
Review Of Zebrafish Models To Boost Research In Rare Genetic Diseases
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Nutraceuticals & New approaches to DMD treatment
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Lost and Found: Zebrafish as a Drug Discovery Tool
Neuroscience Models: Transgenic Mice, Zebrafish, C. Elegans – And Jellyfish?
How Probiotics are Being Used to Combat COVID-19
What’s Tau Got to Do With it?
Modeling Gut Microbiome Effects In Alternative Animal Models – Finding The Happy Biota For A Long And Healthy Life
One Fish in a Large Pond: History of the Zebrafish and Other Fish Models for Research Applications
Unraveling Rare Disease Mysteries: CRISPR and Humanized Models in STXBP1 Research
Rising Healthcare Costs? Non-Mammalian Models To The Rescue
Creating Transgenic C. elegans Models For Clinical Variants of Unknown Significance [Customer Story]
Toxicity Screening: A New Generation Of Models
What the Undiagnosed Diseases Network is, How it Works, and How InVivo Biosystems is Doing its Part
The Lasting Effects Of COVID-19 On Research Labs
From Unknown to Known: How the Zebrafish Model is Playing a Vital Role in the Undiagnosed Diseases Network
The Application of Hypersensitivity Assays to the Discovery of Therapeutics
The 3Rs of Animal Research: Are the guidelines working? How can we do better?
So What is Humanization?
The Good, Bad and the Ugly of Reactive Oxygen Species
The Next Generation of Animal Models: Humanized Models
An Updated Comparison of Common Model Organisms Part 3: Organisms for Modeling Alzheimer’s Disease
An Updated Comparison of Common Model Organisms Part 2: Organisms for Modeling Epilepsy
According to the Epilepsy Foundation 1 in 26 people in the U.S.A will develop epilepsy at some point in their life, however, epilepsy is a
An Updated Comparison of Common Model Organisms
Model organisms are essential to experimental research, allowing researchers and scientists to address a variety of questions. While no model is perfect, some models are
Alzheimer’s – Have we been approaching it all wrong?
A new finding has set the Alzheimer’s research world abuzz: a 73- year old woman with extremely high risk for AD, yet who doesn’t have
Whole Gene Humanization for Personalized Medicine Applications
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for
Why C. elegans are ideal for Disease Modeling [Infographic]
Did you know C. elegans are an ideal model for disease modeling? It may seem unlikely that such a tiny animal would work well for
How to Design a Good Phenotype Based Drug Discovery Program, and Why It Matters.
With the advent of the molecular biology revolution and the human genome project in the 1990s there was a historic shift toward target-based drug
90 Mutations with 1 Gene: Functional Analysis of Variants Using C. elegans
We created over 90 point mutations in the STXBP1 gene via CRISPR. A map of these point mutations can be seen above. Clinical variants
Understanding GPCRs Using Humanized C. elegans
Our CSO, Dr. Chris Hopkins presented at DR. GPCR SUMMIT 2020 on why C. elegans is an ideal model to study the underlying principles of GPCRs.
Zebrafish Modeling Of SARS-CoV-2 Susceptibility In Rare Disease
The Need for Animal Models in COVID-19 Research
Our CSO recently helped write a letter expressing the need for animal models in COVID-19 research
Research Spotlight: Summer Sun Safety Month
C. elegans and Zebrafish have been used to study the effects of ultraviolet radiation (UVR) for decades. August is Summer Sun Safety Month so in
Longevity Studies Using C. elegans to Identify Potential Anti-Aging Compounds [Customer Story]
Dr. Vollmer shares his experience working with us and how the Longevity Platform delivers the results he needs within his timeline and budget.
A View From the Bench: Roadblocks and Frustrations When Expectation Meets Reality.
In an effort to create better models for epilepsy, we’ve been working on a grant-funded project to humanize important synaptic machinery by replacing endogenous coding
Research Spotlight: Alzheimer’s Disease
June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking
Seventeen Minutes of Science: Viral Gene Therapies and Their Potential Use Against COVID-19
Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook
Alzheimer’s Awareness Month [Infographic]
The Importance of COVID-19 Environmental Testing
Originally posted on the Enviral Tech website. Read it on their site here. Why you should start testing your facilities for COVID-19 now As COVID-19
Bacteria, Protozoa And Nematodes, Oh My!: Seeking New Drugs Against COVID-19
Seventeen Minutes of Science: Modeling Human Diseases in Zebrafish (Episode 4)
Seventeen Minutes of Science: The More Models the Merrier – Zebrafish & C. elegans Working Together (Episode 3)
Seventeen Minutes of Science: Virology & World Health (Episode 2)
Zebrafish modeling for the clinic: Rapid in vivo functional testing of patient variants for clinical applications.
We use the zebrafish (Danio rerio) as an in vivo model to measure the functional effects of patient-derived genetic variation.  In this way, human genetic variants identified
Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap
While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease,
CRISPR technologies enable humanized animal models to aid disease research
C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of
Arg…What’s up with that? Arginine is Enriched in Pathogenic Variants
Our CSO explores a theory he has about the amino acid arginine which seems to be showing frequent association with pathogenicity.
Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead
Neurotoxin exposure is implicated in the etiology of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease and ALS (amyotrophic lateral sclerosis). Traditionally, vertebrate animals such as
The Precisome™ Platform Bridges the ACDY5 Diagnostic Gap
NemaMetrix is the market leader for early preclinical in-vivo testing using small animal models to gain a better understanding of the efficacy, mode of action,
[Review] The Human Avatar
NemaMetrix is the market leader for early preclinical in-vivo testing using small animal models to gain a better understanding of the efficacy, mode of action,
Reviewers’ Choice Abstract Award at ASHG Goes to Ben Jussila for Demonstrating how Zebrafish Can be Used for Disease Modeling
Bayer and NemaMetrix present C. elegans results at Parasitic Helminths conference in Greece
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
Hurricanes and Heartworms; Extreme Weather Events Spread Worms
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
The Evolution of Drug Resistance; an Issue of “When, not if”
Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal
Total Domination – Uncovering the Phenomenon of 1:2 Dominant vs Recessive ratio for Variation in the Genome
Our CSO revisits his Veritas Genomic Sequencing report for a closer look at how significant some of the discovered variants are
[Case Study] Exploring the Potential
NemaMetrix is the market leader for early preclinical in-vivo testing using small animal models to gain a better understanding of the efficacy, mode of action,
A New Approach to Anti-Aging Research
The shift towards preventive medicine has given anti-aging startups a favorable environment in pursuing longevity and aging issues. The nematode C. elegans has emerged to
[Case Study] From Worm to Pre-Clinical Data
NemaMetrix is the market leader for early preclinical in-vivo testing using small animal models to gain a better understanding of the efficacy, mode of action,
Worming into Relevance – How C. elegans Can Help us Understand Human Health
Animal testing in the research-based pharmaceutical industry has been reduced in recent years both for ethical and cost reasons. However, it is still a staple
Genomic baggage – What are the skeletons rattling in your genetic closet?
When you receive your genomic report, you have a movement of trepidation.What will it say? Will it have something that says you should do countermeasures
What Can Zebrafish Tell us About CRISPR Off-Target Activity?
In 2017, a now-redacted paper published in Nature Methods claimed that CRISPR created hundreds of unintended mutations in mouse models, and that algorithms designed to
C. elegans showing its weight in neuro-toxicology research
The Humanized Worm [Infographic]
Humanized model organisms are powerful biological models that allow scientists to study human disease genes in simpler contexts without losing the value of in vivo
The Unnecessary Procedure – A Problem with False Positives in Genomic Testing
There is a significant pressure to increase diagnostic yield and it has its consequences. BRCA testing is probably the most developed ecosystem for genetic tests
Using C. elegans to study parasitism
C. elegans is one of the most powerful model organisms and has been used to unravel several key genetic pathways. The C. elegans nematode has been used
Child Neurology Meeting: Bernard Sachs Award to William B. Dobyns and Precision Medicine in Epilepsy Lecture
The Child Neurology Society honored William (Bill) Dobyns for his highly impactful efforts in characterizing child neurology. In a prolific and highly influential carrier, Bill
Explosive Growth of Gene Variant Numbers
Genetic Testing Clinical geneticists have an acute need to understand pathogenicity in genomes of their patients (Figure 1). Cost per human genome has now approached
Systems for Improving Diagnostic Yield of Genomic Sequence Analysis
How to better understanding Variants of Uncertain Significance in epilepsy and help find new therapeutic approaches Did you know that 1 in 26 people will
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