fbpx
Search
Close this search box.
Contact Us

InVivo Biosystems Blog

Category: Disease Modeling

Humanized C. elegans Models for Epilepsy Drug Development
By:
Ally Wimberly ,
READ MORE
Accelerating Alzheimer’s Treatment: Fast and Effective Preclinical Development
By:
Ally Wimberly ,
READ MORE
Huntington’s Disease: Revolutionizing Drug Discovery with Fast In Vivo Models
By:
Ally Wimberly ,
READ MORE
Parkinson’s Takes Decades to Develop–Zebrafish Provides Answers Within Days.
By:
Laura Taggart-Murphy ,
Ally Wimberly ,
READ MORE
Overcoming the Challenging Nature of Knock-Ins in Zebrafish
By:
Gianna DeMarco ,
Marnie Preston ,
READ MORE
Unraveling Epilepsy: Modeling Dravet Syndrome in Zebrafish
By:
Joseph Bruckner ,
Stacy Levichev ,
READ MORE
Cultivating hope for STXBP1 epilepsy patients – an inspiring interview with Lior Dor and Sagi Gidali
By:
Ally Wimberly ,
READ MORE
Alternative Animal Models Unlock Hope in STXBP1 Epilepsy Research
By:
Ally Wimberly ,
READ MORE
Preclinical Drug Discovery | InVivo Biosystems
Biological Quality Control Assay Validation Services
By:
Ally Wimberly ,
READ MORE
CRISPR ZEBRAFISH KNOCKIN | InVivo Biosystems
Modeling Anxiety and Stress in Zebrafish: Thigmotaxis
By:
Ally Wimberly ,
READ MORE
Zebrafish vs. Mouse Models: A New Standard in Behavioral Assays
By:
Ally Wimberly ,
READ MORE
Rapid Results: The RapidGen™ CRISPR Approach
By:
Ally Wimberly ,
READ MORE
Using Zebrafish to Combat Cognitive Decline: How a Biopharmaceutical Company Leveraged a Zebrafish Model to characterize a Compound for Neurodegenerative Disease Therapeutics
By:
Alexandra Narin ,
Joseph Bruckner ,
READ MORE
Speeding up the diagnostic journey for Rare Disease patients: An in vivo discovery platform that helps classify variants of uncertain significance
By:
Chris Hopkins ,
Alexandra Narin ,
READ MORE
How to Attain IND Approval Faster
By:
Ally Wimberly ,
Alexandra Narin ,
READ MORE
Fast, Cost Effective Compound Efficacy Testing using Zebrafish
By:
Alexandra Narin ,
READ MORE
Better Together? Zebrafish and Mice Models should be utilized in Conjunction.
By:
Alexandra Narin ,
READ MORE
feature image for humanized customer story updates
A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia [Where are they now: Customer Story]
By:
Alexandra Narin ,
READ MORE
For Studying Host-Microbe Interactions, Why Choose Zebrafish?
By:
Alexandra Narin ,
Joseph Bruckner ,
READ MORE
Leaky gut assays feature image
Leaky Gut Assays in Animal Models
By:
Alexandra Narin ,
Chris Hopkins ,
READ MORE
zebrafish as a unique model to research organ regeneration
As a Researcher, Why Choose Zebrafish? Unique Models: Organ Regeneration
By:
Laura Taggart-Murphy ,
Alexandra Narin ,
READ MORE
FDA Modernization Act 3.0: Alternative Animal Models are Transforming Drug Development
By:
Alexandra Narin ,
READ MORE
image of fluorescent zebrafish blog post image
Zebrafish researchers lack enough tools to efficiently and accurately quantify immune responses. Monoclonal antibodies could change that.
By:
Alexandra Narin ,
READ MORE
why chose zebrafish as a model
As a Researcher, Why Choose Zebrafish?
By:
Alexandra Narin ,
READ MORE
WHAM with CRISPR - re-imaging how rare disease therapeutics are developed
Whole-gene Humanized Animal Models (WHAM) with CRISPR – Re-imagining how Rare Disease therapeutics are developed
By:
Chris Hopkins ,
Alexandra Narin ,
READ MORE
America is finally investing in Biotechnology & Biomanufacturing in a Big Way
By:
Alexandra Narin ,
READ MORE
[Patent Announcement] InVivo Biosystems has officially been issued a patent on WHAM-humanization in the nematode, C. elegans
By:
Alexandra Narin ,
READ MORE
Looking at Gene Paralogs across both zebrafish and C. elegans Model Organisms [Customer Story]
By:
Alexandra Narin ,
READ MORE
Healthy Aging and Longevity Research is on the Rise – which is the Best Model Organism to use?
By:
Alexandra Narin ,
READ MORE
Chemicals Models of Parkinson’s Disease in Larval Zebrafish
By:
Laura Taggart-Murphy ,
Alexandra Narin ,
READ MORE
Review: How a Small Worm is Helping Uncover the Pathogenicity of Gene Variants
By:
Ben Jussila ,
Alexandra Narin ,
READ MORE
Using Zebrafish as a Model for Opioid Addiction with Dr. Gabriel Bossé (University of Utah)
By:
Hannah Huston ,
READ MORE
A Natural Fit – Using Zebrafish to Evaluate Natural Compounds for Anti-Inflammatory Properties
By:
Laura Taggart-Murphy ,
Alexandra Narin ,
READ MORE
Temperature & C. elegans Part Two: How does Temperature affect development?
By:
Christine Kim ,
Thomas Adams ,
READ MORE
Zebrafish 101: A White Paper
By:
Alexandra Narin ,
READ MORE
C. elegans 101: A White Paper
By:
Alexandra Narin ,
READ MORE
Review Of Zebrafish Models To Boost Research In Rare Genetic Diseases
By:
Alexandra Narin ,
READ MORE
DMD feature image
Nutraceuticals & New approaches to DMD treatment
By:
Alexandra Narin ,
READ MORE
zfish as drug discovery tool feature image
Lost and Found: Zebrafish as a Drug Discovery Tool
By:
Alexandra Narin ,
READ MORE
Neuroscience Models: Transgenic Mice, Zebrafish, C. Elegans – And Jellyfish?
By:
Alexandra Narin ,
READ MORE
How Probiotics are Being Used to Combat COVID-19
By:
Alexandra Narin ,
READ MORE
What’s Tau Got to Do With it?
By:
Alexandra Narin ,
READ MORE
Modeling Gut Microbiome Effects In Alternative Animal Models – Finding The Happy Biota For A Long And Healthy Life
By:
Alexandra Narin ,
Hannah Huston ,
Chris Hopkins ,
READ MORE
One Fish in a Large Pond: History of the Zebrafish and Other Fish Models for Research Applications
By:
Ashwin Suresh ,
Alexandra Narin ,
READ MORE
Unraveling Rare Disease Mysteries: CRISPR and Humanized Models in STXBP1 Research
By:
Alexandra Narin ,
READ MORE
Rising Healthcare Costs? Non-Mammalian Models To The Rescue
By:
Alexandra Narin ,
READ MORE
Toxicity Screening: A New Generation Of Models
By:
Alexandra Narin ,
READ MORE
What the Undiagnosed Diseases Network is, How it Works, and How InVivo Biosystems is Doing its Part
By:
Ashwin Suresh ,
Alexandra Narin ,
Ben Jussila ,
READ MORE
The Lasting Effects Of COVID-19 On Research Labs
By:
Alexandra Narin ,
READ MORE
From Unknown to Known: How the Zebrafish Model is Playing a Vital Role in the Undiagnosed Diseases Network
By:
Ashwin Suresh ,
Alexandra Narin ,
READ MORE
The 3Rs of Animal Research: Are the guidelines working? How can we do better?
By:
Alexandra Narin ,
READ MORE
So What is Humanization?
By:
Alexandra Narin ,
READ MORE
The Good, Bad and the Ugly of Reactive Oxygen Species
By:
Chris Hopkins ,
READ MORE
The Next Generation of Animal Models: Humanized Models
By:
Alexandra Narin ,
READ MORE
An Updated Comparison of Common Model Organisms Part 3: Organisms for Modeling Alzheimer’s Disease
By:
Alexandra Narin ,
READ MORE
An Updated Comparison of Common Model Organisms Part 2: Organisms for Modeling Epilepsy
By:
Alexandra Narin ,
According to the Epilepsy Foundation 1 in 26 people in the U.S.A will develop epilepsy at some point in their life, however, epilepsy is a
READ MORE
An Updated Comparison of Common Model Organisms
By:
Alexandra Narin ,
Model organisms are essential to experimental research, allowing researchers and scientists to address a variety of questions. While no model is perfect, some models are
READ MORE
Alzheimer’s – Have we been approaching it all wrong?
By:
Alexandra Narin ,
A new finding has set the Alzheimer’s research world abuzz: a 73- year old woman with extremely high risk for AD, yet who doesn’t have
READ MORE
Whole Gene Humanization for Personalized Medicine Applications
By:
Chris Hopkins ,
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for
READ MORE
Why C. elegans are ideal for Disease Modeling [Infographic]
By:
InVivo Biosystems ,
Did you know C. elegans are an ideal model for disease modeling? It may seem unlikely that such a tiny animal would work well for
READ MORE
How to Design a Good Phenotype Based Drug Discovery Program, and Why It Matters.
By:
Kathryn McCormick ,
With the advent of the molecular biology revolution and the human genome project in the 1990s there was a historic shift toward target-based drug development.
READ MORE
90 Mutations with 1 Gene: Functional Analysis of Variants Using C. elegans
By:
Trisha Brock ,
Kathryn McCormick ,
We created over 90 point mutations in the STXBP1 gene via CRISPR. A map of these point mutations can be seen above. Clinical variants were
READ MORE
Understanding GPCRs Using Humanized C. elegans
By:
InVivo Biosystems ,
Our CSO, Dr. Chris Hopkins presented at DR. GPCR SUMMIT 2020 on why C. elegans is an ideal model to study the underlying principles of
READ MORE
Zebrafish Modeling Of SARS-CoV-2 Susceptibility In Rare Disease
By:
Chris Hopkins ,
READ MORE
Alzheimer’s Disease: Premium in vivo SEP1, MAPT, and Aß Models
By:
Ally Wimberly ,
June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking
READ MORE
Seventeen Minutes of Science: Viral Gene Therapies and Their Potential Use Against COVID-19
By:
InVivo Biosystems ,
Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook
READ MORE
Seventeen Minutes of Science: Modeling Human Diseases in Zebrafish (Episode 4)
By:
Hannah Huston ,
READ MORE
Seventeen Minutes of Science: Virology & World Health (Episode 2)
By:
Hannah Huston ,
READ MORE
Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap
By:
InVivo Biosystems ,
While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease,
READ MORE
CRISPR technologies enable humanized animal models to aid disease research
By:
InVivo Biosystems ,
C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of
READ MORE
Arg…What’s up with that? Arginine is Enriched in Pathogenic Variants
By:
Chris Hopkins ,
Our CSO explores a theory he has about the amino acid arginine which seems to be showing frequent association with pathogenicity.
READ MORE
Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead
By:
Janis Weeks, Ph.D. ,
Neurotoxin exposure is implicated in the etiology of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease and ALS (amyotrophic lateral sclerosis). Traditionally, vertebrate animals such as
READ MORE
Bayer and NemaMetrix present C. elegans results at Parasitic Helminths conference in Greece
By:
Janis Weeks, Ph.D. ,
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
READ MORE
Hurricanes and Heartworms; Extreme Weather Events Spread Worms
By:
Janis Weeks, Ph.D. ,
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
READ MORE
The Evolution of Drug Resistance; an Issue of “When, not if”
By:
Janis Weeks, Ph.D. ,
Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal
READ MORE
Total Domination – Uncovering the Phenomenon of 1:2 Dominant vs Recessive ratio for Variation in the Genome
By:
Chris Hopkins ,
Our CSO revisits his Veritas Genomic Sequencing report for a closer look at how significant some of the discovered variants are
READ MORE
A New Approach to Anti-Aging Research
By:
Yoanne Clovis, Ph.D. ,
The shift towards preventive medicine has given anti-aging startups a favorable environment in pursuing longevity and aging issues. The nematode C. elegans has emerged to
READ MORE
Worming into Relevance – How C. elegans Can Help us Understand Human Health
By:
Yoanne Clovis, Ph.D. ,
Animal testing in the research-based pharmaceutical industry has been reduced in recent years both for ethical and cost reasons. However, it is still a staple
READ MORE
Genomic baggage – What are the skeletons rattling in your genetic closet?
By:
Chris Hopkins ,
When you receive your genomic report, you have a movement of trepidation.What will it say? Will it have something that says you should do countermeasures
READ MORE
The Humanized Worm [Infographic]
By:
Ally Wimberly ,
Humanized model organisms are powerful biological models that allow scientists to study human disease genes in simpler contexts without losing the value of in vivo
READ MORE
The Unnecessary Procedure – A Problem with False Positives in Genomic Testing
By:
Chris Hopkins ,
There is a significant pressure to increase diagnostic yield and it has its consequences. BRCA testing is probably the most developed ecosystem for genetic tests
READ MORE
Using C. elegans to study parasitism
By:
Ramesh Ratnappan ,
C. elegans is one of the most powerful model organisms and has been used to unravel several key genetic pathways. The C. elegans nematode has
READ MORE
Child Neurology Meeting: Bernard Sachs Award to William B. Dobyns and Precision Medicine in Epilepsy Lecture
By:
Chris Hopkins ,
The Child Neurology Society honored William (Bill) Dobyns for his highly impactful efforts in characterizing child neurology. In a prolific and highly influential carrier, Bill
READ MORE
Explosive Growth of Gene Variant Numbers
By:
Chris Hopkins ,
Genetic Testing Clinical geneticists have an acute need to understand pathogenicity in genomes of their patients (Figure 1). Cost per human genome has now approached
READ MORE
Systems for Improving Diagnostic Yield of Genomic Sequence Analysis
By:
Chris Hopkins ,
How to better understanding Variants of Uncertain Significance in epilepsy and help find new therapeutic approaches Did you know that 1 in 26 people will
READ MORE
A New Era of Transgenics in Parasitic Nematodes
By:
Ramesh Ratnappan ,
One of the most commonly known nematodes in the scientific community is Caenorhabditis elegans. Ever since Sydney Brenner introduced it as a model organism to
READ MORE
C. elegans as Fast and Affordable System for Variant Phenotyping
By:
Chris Hopkins ,
Systems for Functional Studies A variety of modeling systems can be used to explore variant function. Initially, many researchers turn to a computational approach to
READ MORE
Worming into Relevance – Human disease models in the C. elegans nematode
By:
Chris Hopkins ,
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
READ MORE
KCNQ2 epilepsy gene
Functional analysis of variants to aid understanding of children’s epilepsy
By:
InVivo Biosystems ,
Performing sequence analysis on a patient with a suspected genetic disease is becoming a standard of care. However, when a genetic variation is identified as
READ MORE
KCNQ2 Cures Summit – Patient Family Passion and Involvement
By:
Chris Hopkins ,
The passion to find answers is inspiring. I had the good fortune to attend the KCNQ2 Cure Summit 2018. Meeting the patient families and seeing
READ MORE
Worming into Relevance – Human disease models in the C. elegans nematode
By:
Chris Hopkins ,
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
READ MORE
Properties of Top 20 Epilepsy Genes
By:
Chris Hopkins ,
Epilepsy Genetics 1 out of 100 persons is living with active epilepsy (Zack and Kobau 2017, WHO 2018). For the subset that can be pinned
READ MORE
DD News features NemaMetrix in its latest issue on Animal Models of Disease
By:
InVivo Biosystems ,
The latest issue of Drug Discovery News (DDNews) features a special report on Animal Models of Disease, highlighting the NemaMetrix/Knudra merger and the value of
READ MORE
Dr. Andy Golden
Unlocking the Potential of C. elegans for the Study of Rare Disease
By:
InVivo Biosystems ,
Dr. Andy Golden at NIH discusses his work on identifying regulators and interactors of conserved genes in C. elegans that, when mutated, can cause human
READ MORE
Scientists study how cancer spreads by recording a time-lapse of C. elegans
By:
Matt Beaudet, CEO ,
Scientists from Duke University captured the cellular break-ins in C. elegans, a transparent worm that’s often used as a model for human biology. The cellular
READ MORE
C. elegans in cancer research
By:
Yoanne Clovis, Ph.D. ,
In recent years, the nematode C. elegans has emerged as a model for systematic dissection of the molecular basis of tumorigenesis. Many cancer genes and
READ MORE
Deciphering Breast Cancer with C. elegans – A Case Study
By:
Yoanne Clovis, Ph.D. ,
In recent years, the nematode C. elegans has emerged as a model for systematic dissection of the molecular basis of tumorigenesis. Many cancer genes and
READ MORE
Modeling Rare Diseases in Caenorhabditis elegans
By:
Shawn Lockery, Ph.D., Co-founder ,
There are approximately 7,000 rare diseases in humans, ~80% of which are monogenic. A rare disease is defined as affecting less than one in 1,500
READ MORE
Aging studies use C. elegans to test bacterial genes
By:
Matt Beaudet, CEO ,
Interesting data using C. elegans for studying the impact your gut microbiome may have on your lifespan and healthspan from the Wang Lab at Baylor
READ MORE
New phenotype discovered for NPC disease using C. elegans
By:
InVivo Biosystems ,
We discovered that in the absence of cholesterol, NPC mutants display a lower pharyngeal pumping frequency and a longer duration between pumps than control N2
READ MORE
Load More
  • Categories

    • Connect with us

    Facebook Twitter Linkedin
    stay on the cutting edge...

    The InVivo Biosystems Newsletter is delivered to your inbox bi-weekly,
    giving you all of the latest company updates, industry news, and more.

    Sign Up

    Built on a robust portfolio of CRISPR genome editing patents, InVivo Biosystems has established a comprehensive preclinical discovery and development platform. By leveraging alternative models and proprietary methods, we accelerate go-to-market timelines for pharmaceutical companies and beyond.

    Quick Links
    Contact Us

    Headquarters: 1505 Westec Drive, Eugene, OR 97402

    1.844.663.8749.

    Facebook Twitter Linkedin
    Copyright © 2022 InVivo Biosystems. All rights reserved.
    Facebook Twitter Linkedin