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InVivo Biosystems Blog

Huntington’s Disease: Revolutionizing Drug Discovery with Fast In Vivo Models
Parkinson’s Takes Decades to Develop–Zebrafish Provides Answers Within Days.
Overcoming the Challenging Nature of Knock-Ins in Zebrafish
Unraveling Epilepsy: Modeling Dravet Syndrome in Zebrafish
Cultivating hope for STXBP1 epilepsy patients – an inspiring interview with Lior Dor and Sagi Gidali
Alternative Animal Models Unlock Hope in STXBP1 Epilepsy Research
Preclinical Drug Discovery | InVivo Biosystems
Biological Quality Control Assay Validation Services
CRISPR ZEBRAFISH KNOCKIN | InVivo Biosystems
Modeling Anxiety and Stress in Zebrafish: Thigmotaxis
Zebrafish vs. Mouse Models: A New Standard in Behavioral Assays
Rapid Results: The RapidGen™ CRISPR Approach
Using Zebrafish to Combat Cognitive Decline: How a Biopharmaceutical Company Leveraged a Zebrafish Model to characterize a Compound for Neurodegenerative Disease Therapeutics
Speeding up the diagnostic journey for Rare Disease patients: An in vivo discovery platform that helps classify variants of uncertain significance
Whitepaper: What is IND?
Fast, Cost Effective Compound Efficacy Testing using Zebrafish
Better Together? Zebrafish and Mice Models should be utilized in Conjunction.
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A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia [Where are they now: Customer Story]
For Studying Host-Microbe Interactions, Why Choose Zebrafish?
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Leaky Gut Assays in Animal Models
zebrafish as a unique model to research organ regeneration
As a Researcher, Why Choose Zebrafish? Unique Models: Organ Regeneration
FDA Modernization Act 3.0: Alternative Animal Models are Transforming Drug Development
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Zebrafish researchers lack enough tools to efficiently and accurately quantify immune responses. Monoclonal antibodies could change that.
why chose zebrafish as a model
As a Researcher, Why Choose Zebrafish?
WHAM with CRISPR - re-imaging how rare disease therapeutics are developed
Whole-gene Humanized Animal Models (WHAM) with CRISPR – Re-imagining how Rare Disease therapeutics are developed
America is finally investing in Biotechnology & Biomanufacturing in a Big Way
[Patent Announcement] InVivo Biosystems has officially been issued a patent on WHAM-humanization in the nematode, C. elegans
Looking at Gene Paralogs across both zebrafish and C. elegans Model Organisms [Customer Story]
Healthy Aging and Longevity Research is on the Rise – which is the Best Model Organism to use?
Chemicals Models of Parkinson’s Disease in Larval Zebrafish
Review: How a Small Worm is Helping Uncover the Pathogenicity of Gene Variants
Using Zebrafish as a Model for Opioid Addiction with Dr. Gabriel Bossé (University of Utah)
A Natural Fit – Using Zebrafish to Evaluate Natural Compounds for Anti-Inflammatory Properties
Temperature & C. elegans Part Two: How does Temperature affect development?
Zebrafish 101: A White Paper
C. elegans 101: A White Paper
Review Of Zebrafish Models To Boost Research In Rare Genetic Diseases
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Nutraceuticals & New approaches to DMD treatment
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Lost and Found: Zebrafish as a Drug Discovery Tool
Neuroscience Models: Transgenic Mice, Zebrafish, C. Elegans – And Jellyfish?
How Probiotics are Being Used to Combat COVID-19
What’s Tau Got to Do With it?
Modeling Gut Microbiome Effects In Alternative Animal Models – Finding The Happy Biota For A Long And Healthy Life
One Fish in a Large Pond: History of the Zebrafish and Other Fish Models for Research Applications
Unraveling Rare Disease Mysteries: CRISPR and Humanized Models in STXBP1 Research
Rising Healthcare Costs? Non-Mammalian Models To The Rescue
Toxicity Screening: A New Generation Of Models
What the Undiagnosed Diseases Network is, How it Works, and How InVivo Biosystems is Doing its Part
The Lasting Effects Of COVID-19 On Research Labs
From Unknown to Known: How the Zebrafish Model is Playing a Vital Role in the Undiagnosed Diseases Network
The 3Rs of Animal Research: Are the guidelines working? How can we do better?
So What is Humanization?
The Good, Bad and the Ugly of Reactive Oxygen Species
The Next Generation of Animal Models: Humanized Models
An Updated Comparison of Common Model Organisms Part 3: Organisms for Modeling Alzheimer’s Disease
An Updated Comparison of Common Model Organisms Part 2: Organisms for Modeling Epilepsy
According to the Epilepsy Foundation 1 in 26 people in the U.S.A will develop epilepsy at some point in their life, however, epilepsy is a
An Updated Comparison of Common Model Organisms
Model organisms are essential to experimental research, allowing researchers and scientists to address a variety of questions. While no model is perfect, some models are
Alzheimer’s – Have we been approaching it all wrong?
A new finding has set the Alzheimer’s research world abuzz: a 73- year old woman with extremely high risk for AD, yet who doesn’t have
Whole Gene Humanization for Personalized Medicine Applications
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for
Why C. elegans are ideal for Disease Modeling [Infographic]
Did you know C. elegans are an ideal model for disease modeling? It may seem unlikely that such a tiny animal would work well for
How to Design a Good Phenotype Based Drug Discovery Program, and Why It Matters.
With the advent of the molecular biology revolution and the human genome project in the 1990s there was a historic shift toward target-based drug development.
90 Mutations with 1 Gene: Functional Analysis of Variants Using C. elegans
We created over 90 point mutations in the STXBP1 gene via CRISPR. A map of these point mutations can be seen above. Clinical variants were
Understanding GPCRs Using Humanized C. elegans
Our CSO, Dr. Chris Hopkins presented at DR. GPCR SUMMIT 2020 on why C. elegans is an ideal model to study the underlying principles of
Zebrafish Modeling Of SARS-CoV-2 Susceptibility In Rare Disease
Research Spotlight: Alzheimer’s Disease
June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking
Seventeen Minutes of Science: Viral Gene Therapies and Their Potential Use Against COVID-19
Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook
Seventeen Minutes of Science: Modeling Human Diseases in Zebrafish (Episode 4)
Seventeen Minutes of Science: Virology & World Health (Episode 2)
Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap
While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease,
CRISPR technologies enable humanized animal models to aid disease research
C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of
Arg…What’s up with that? Arginine is Enriched in Pathogenic Variants
Our CSO explores a theory he has about the amino acid arginine which seems to be showing frequent association with pathogenicity.
Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead
Neurotoxin exposure is implicated in the etiology of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease and ALS (amyotrophic lateral sclerosis). Traditionally, vertebrate animals such as
Bayer and NemaMetrix present C. elegans results at Parasitic Helminths conference in Greece
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
Hurricanes and Heartworms; Extreme Weather Events Spread Worms
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
The Evolution of Drug Resistance; an Issue of “When, not if”
Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal
Total Domination – Uncovering the Phenomenon of 1:2 Dominant vs Recessive ratio for Variation in the Genome
Our CSO revisits his Veritas Genomic Sequencing report for a closer look at how significant some of the discovered variants are
A New Approach to Anti-Aging Research
The shift towards preventive medicine has given anti-aging startups a favorable environment in pursuing longevity and aging issues. The nematode C. elegans has emerged to
Worming into Relevance – How C. elegans Can Help us Understand Human Health
Animal testing in the research-based pharmaceutical industry has been reduced in recent years both for ethical and cost reasons. However, it is still a staple
Genomic baggage – What are the skeletons rattling in your genetic closet?
When you receive your genomic report, you have a movement of trepidation.What will it say? Will it have something that says you should do countermeasures
The Humanized Worm [Infographic]
Humanized model organisms are powerful biological models that allow scientists to study human disease genes in simpler contexts without losing the value of in vivo
The Unnecessary Procedure – A Problem with False Positives in Genomic Testing
There is a significant pressure to increase diagnostic yield and it has its consequences. BRCA testing is probably the most developed ecosystem for genetic tests
Using C. elegans to study parasitism
C. elegans is one of the most powerful model organisms and has been used to unravel several key genetic pathways. The C. elegans nematode has
Child Neurology Meeting: Bernard Sachs Award to William B. Dobyns and Precision Medicine in Epilepsy Lecture
The Child Neurology Society honored William (Bill) Dobyns for his highly impactful efforts in characterizing child neurology. In a prolific and highly influential carrier, Bill
Explosive Growth of Gene Variant Numbers
Genetic Testing Clinical geneticists have an acute need to understand pathogenicity in genomes of their patients (Figure 1). Cost per human genome has now approached
Systems for Improving Diagnostic Yield of Genomic Sequence Analysis
How to better understanding Variants of Uncertain Significance in epilepsy and help find new therapeutic approaches Did you know that 1 in 26 people will
A New Era of Transgenics in Parasitic Nematodes
One of the most commonly known nematodes in the scientific community is Caenorhabditis elegans. Ever since Sydney Brenner introduced it as a model organism to
C. elegans as Fast and Affordable System for Variant Phenotyping
Systems for Functional Studies A variety of modeling systems can be used to explore variant function. Initially, many researchers turn to a computational approach to
Worming into Relevance – Human disease models in the C. elegans nematode
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
KCNQ2 epilepsy gene
Functional analysis of variants to aid understanding of children’s epilepsy
Performing sequence analysis on a patient with a suspected genetic disease is becoming a standard of care. However, when a genetic variation is identified as
KCNQ2 Cures Summit – Patient Family Passion and Involvement
The passion to find answers is inspiring. I had the good fortune to attend the KCNQ2 Cure Summit 2018. Meeting the patient families and seeing
Worming into Relevance – Human disease models in the C. elegans nematode
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
Properties of Top 20 Epilepsy Genes
Epilepsy Genetics 1 out of 100 persons is living with active epilepsy (Zack and Kobau 2017, WHO 2018). For the subset that can be pinned
DD News features NemaMetrix in its latest issue on Animal Models of Disease
The latest issue of Drug Discovery News (DDNews) features a special report on Animal Models of Disease, highlighting the NemaMetrix/Knudra merger and the value of
Dr. Andy Golden
Unlocking the Potential of C. elegans for the Study of Rare Disease
Dr. Andy Golden at NIH discusses his work on identifying regulators and interactors of conserved genes in C. elegans that, when mutated, can cause human
Scientists study how cancer spreads by recording a time-lapse of C. elegans
Scientists from Duke University captured the cellular break-ins in C. elegans, a transparent worm that’s often used as a model for human biology. The cellular
C. elegans in cancer research
In recent years, the nematode C. elegans has emerged as a model for systematic dissection of the molecular basis of tumorigenesis. Many cancer genes and
Deciphering Breast Cancer with C. elegans – A Case Study
In recent years, the nematode C. elegans has emerged as a model for systematic dissection of the molecular basis of tumorigenesis. Many cancer genes and
Modeling Rare Diseases in Caenorhabditis elegans
There are approximately 7,000 rare diseases in humans, ~80% of which are monogenic. A rare disease is defined as affecting less than one in 1,500
Aging studies use C. elegans to test bacterial genes
Interesting data using C. elegans for studying the impact your gut microbiome may have on your lifespan and healthspan from the Wang Lab at Baylor
New phenotype discovered for NPC disease using C. elegans
We discovered that in the absence of cholesterol, NPC mutants display a lower pharyngeal pumping frequency and a longer duration between pumps than control N2
The cerebellum of a brain affected by Niemann-Pick Type C; blue staining shows the dense pockets of lipid accumulations throughout the brain
Searching for a cure for Niemann-Pick Type C using C. elegans
Niemann-Pick Type C is a rare and fatal disorder affecting children. We explore the efficacy of new potential therapeutics with the ScreenChip System.
Duration of pharyngeal contraction
Health markers are impaired in aging C. elegans
C. elegans’ feeding behavior strongly influences the worm’s aging and longevity. We tested adult worms to quantify how aging affects their feeding behavior. In older
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