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InVivo Biosystems Blog

Category: Disease Modeling

Parkinson’s Takes Decades to Develop–Zebrafish Provides Answers Within Days.
By:
Adam Saunders ,
Laura Taggart-Murphy ,
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Overcoming the Challenging Nature of Knock-Ins in Zebrafish
By:
Gianna DeMarco ,
Marnie Preston ,
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Unraveling Epilepsy: Modeling Dravet Syndrome in Zebrafish
By:
Joseph Bruckner ,
Stacy Levichev ,
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Cultivating hope for STXBP1 epilepsy patients – an inspiring interview with Lior Dor and Sagi Gidali
By:
Adam Saunders ,
Ally Wimberly ,
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Alternative Animal Models Unlock Hope in STXBP1 Epilepsy Research
By:
Adam Saunders ,
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Preclinical Drug Discovery | InVivo Biosystems
Biological Quality Control Assay Validation Services
By:
Ally Wimberly ,
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CRISPR ZEBRAFISH KNOCKIN | InVivo Biosystems
Modeling Anxiety and Stress in Zebrafish: Thigmotaxis
By:
Adam Saunders ,
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Zebrafish vs. Mouse Models: A New Standard in Behavioral Assays
By:
Adam Saunders ,
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Rapid Results: The RapidGen™ CRISPR Approach
By:
Adam Saunders ,
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Using Zebrafish to Combat Cognitive Decline: How a Biopharmaceutical Company Leveraged a Zebrafish Model to characterize a Compound for Neurodegenerative Disease Therapeutics
By:
Alexandra Narin ,
Joseph Bruckner ,
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Speeding up the diagnostic journey for Rare Disease patients: An in vivo discovery platform that helps classify variants of uncertain significance
By:
Chris Hopkins ,
Alexandra Narin ,
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Whitepaper: What is IND?
By:
Alexandra Narin ,
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Fast, Cost Effective Compound Efficacy Testing using Zebrafish
By:
Alexandra Narin ,
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Better Together? Zebrafish and Mice Models should be utilized in Conjunction.
By:
Alexandra Narin ,
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feature image for humanized customer story updates
A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia [Where are they now: Customer Story]
By:
Alexandra Narin ,
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For Studying Host-Microbe Interactions, Why Choose Zebrafish?
By:
Alexandra Narin ,
Joseph Bruckner ,
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Leaky gut assays feature image
Leaky Gut Assays in Animal Models
By:
Alexandra Narin ,
Chris Hopkins ,
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zebrafish as a unique model to research organ regeneration
As a Researcher, Why Choose Zebrafish? Unique Models: Organ Regeneration
By:
Laura Taggart-Murphy ,
Alexandra Narin ,
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No animals, new drugs, no problem
New drugs, No Animals, No Problem. The FDA announced legislative changes – drugs are no longer required to be tested in animals before moving to human trials. What does that mean?
By:
Alexandra Narin ,
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Zebrafish researchers lack enough tools to efficiently and accurately quantify immune responses. Monoclonal antibodies could change that.
By:
Alexandra Narin ,
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why chose zebrafish as a model
As a Researcher, Why Choose Zebrafish?
By:
Alexandra Narin ,
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WHAM with CRISPR - re-imaging how rare disease therapeutics are developed
Whole-gene Humanized Animal Models (WHAM) with CRISPR – Re-imagining how Rare Disease therapeutics are developed
By:
Chris Hopkins ,
Alexandra Narin ,
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America is finally investing in Biotechnology & Biomanufacturing in a Big Way
By:
Alexandra Narin ,
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Is our Brain Health Reliant on our Gut?
By:
Alexandra Narin ,
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[Patent Announcement] InVivo Biosystems has officially been issued a patent on WHAM-humanization in the nematode, C. elegans
By:
Alexandra Narin ,
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Looking at Gene Paralogs across both zebrafish and C. elegans Model Organisms [Customer Story]
By:
Alexandra Narin ,
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Healthy Aging and Longevity Research is on the Rise – which is the Best Model Organism to use?
By:
Alexandra Narin ,
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Chemicals Models of Parkinson’s Disease in Larval Zebrafish
By:
Laura Taggart-Murphy ,
Alexandra Narin ,
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Review: How a Small Worm is Helping Uncover the Pathogenicity of Gene Variants
By:
Ben Jussila ,
Alexandra Narin ,
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Using Zebrafish as a Model for Opioid Addiction with Dr. Gabriel Bossé (University of Utah)
By:
Hannah Huston ,
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A Natural Fit – Using Zebrafish to Evaluate Natural Compounds for Anti-Inflammatory Properties
By:
Laura Taggart-Murphy ,
Alexandra Narin ,
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Temperature & C. elegans Part Two: How does Temperature affect development?
By:
Christine Kim ,
Thomas Adams ,
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Zebrafish 101: A White Paper
By:
Alexandra Narin ,
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C. elegans 101: A White Paper
By:
Alexandra Narin ,
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Does everyone have digestive issues? — Gut dysbiosis is on the rise.
By:
Alexandra Narin ,
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microbiome models feature image
Models to Research Microbiome
By:
Alexandra Narin ,
Chris Hopkins ,
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Review Of Zebrafish Models To Boost Research In Rare Genetic Diseases
By:
Alexandra Narin ,
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DMD feature image
Nutraceuticals & New approaches to DMD treatment
By:
Alexandra Narin ,
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zfish as drug discovery tool feature image
Lost and Found: Zebrafish as a Drug Discovery Tool
By:
Alexandra Narin ,
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Neuroscience Models: Transgenic Mice, Zebrafish, C. Elegans – And Jellyfish?
By:
Alexandra Narin ,
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How Probiotics are Being Used to Combat COVID-19
By:
Alexandra Narin ,
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What’s Tau Got to Do With it?
By:
Alexandra Narin ,
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Modeling Gut Microbiome Effects In Alternative Animal Models – Finding The Happy Biota For A Long And Healthy Life
By:
Alexandra Narin ,
Hannah Huston ,
Chris Hopkins ,
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One Fish in a Large Pond: History of the Zebrafish and Other Fish Models for Research Applications
By:
Ashwin Suresh ,
Alexandra Narin ,
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Unraveling Rare Disease Mysteries: CRISPR and Humanized Models in STXBP1 Research
By:
Alexandra Narin ,
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Rising Healthcare Costs? Non-Mammalian Models To The Rescue
By:
Alexandra Narin ,
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Creating Transgenic C. elegans Models For Clinical Variants of Unknown Significance [Customer Story]
By:
Alexandra Narin ,
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Toxicity Screening: A New Generation Of Models
By:
Alexandra Narin ,
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What the Undiagnosed Diseases Network is, How it Works, and How InVivo Biosystems is Doing its Part
By:
Ashwin Suresh ,
Alexandra Narin ,
Ben Jussila ,
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The Lasting Effects Of COVID-19 On Research Labs
By:
Alexandra Narin ,
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From Unknown to Known: How the Zebrafish Model is Playing a Vital Role in the Undiagnosed Diseases Network
By:
Ashwin Suresh ,
Alexandra Narin ,
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The 3Rs of Animal Research: Are the guidelines working? How can we do better?
By:
Alexandra Narin ,
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So What is Humanization?
By:
Alexandra Narin ,
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The Good, Bad and the Ugly of Reactive Oxygen Species
By:
Chris Hopkins ,
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The Next Generation of Animal Models: Humanized Models
By:
Alexandra Narin ,
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An Updated Comparison of Common Model Organisms Part 3: Organisms for Modeling Alzheimer’s Disease
By:
Alexandra Narin ,
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An Updated Comparison of Common Model Organisms Part 2: Organisms for Modeling Epilepsy
By:
Alexandra Narin ,
According to the Epilepsy Foundation 1 in 26 people in the U.S.A will develop epilepsy at some point in their life, however, epilepsy is a
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An Updated Comparison of Common Model Organisms
By:
Alexandra Narin ,
Model organisms are essential to experimental research, allowing researchers and scientists to address a variety of questions. While no model is perfect, some models are
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Alzheimer’s – Have we been approaching it all wrong?
By:
Alexandra Narin ,
A new finding has set the Alzheimer’s research world abuzz: a 73- year old woman with extremely high risk for AD, yet who doesn’t have
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Whole Gene Humanization for Personalized Medicine Applications
By:
Chris Hopkins ,
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for
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Why C. elegans are ideal for Disease Modeling [Infographic]
By:
InVivo Biosystems ,
Did you know C. elegans are an ideal model for disease modeling? It may seem unlikely that such a tiny animal would work well for
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How to Design a Good Phenotype Based Drug Discovery Program, and Why It Matters.
By:
Kathryn McCormick ,
With the advent of the molecular biology revolution and the human genome project in the 1990s there was a historic shift toward target-based drug
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90 Mutations with 1 Gene: Functional Analysis of Variants Using C. elegans
By:
Trisha Brock ,
Kathryn McCormick ,
We created over 90 point mutations in the STXBP1 gene via CRISPR. A map of these point mutations can be seen above. Clinical variants
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Understanding GPCRs Using Humanized C. elegans
By:
InVivo Biosystems ,
Our CSO, Dr. Chris Hopkins presented at DR. GPCR SUMMIT 2020 on why C. elegans is an ideal model to study the underlying principles of GPCRs.
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Zebrafish Modeling Of SARS-CoV-2 Susceptibility In Rare Disease
By:
Chris Hopkins ,
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Longevity Studies Using C. elegans to Identify Potential Anti-Aging Compounds [Customer Story]
By:
InVivo Biosystems ,
Dr. Vollmer shares his experience working with us and how the Longevity Platform delivers the results he needs within his timeline and budget.
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Research Spotlight: Alzheimer’s Disease
By:
Kathryn McCormick ,
June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking
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Seventeen Minutes of Science: Viral Gene Therapies and Their Potential Use Against COVID-19
By:
InVivo Biosystems ,
Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook
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Seventeen Minutes of Science: Modeling Human Diseases in Zebrafish (Episode 4)
By:
Hannah Huston ,
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Seventeen Minutes of Science: The More Models the Merrier – Zebrafish & C. elegans Working Together (Episode 3)
By:
Hannah Huston ,
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Seventeen Minutes of Science: Virology & World Health (Episode 2)
By:
Hannah Huston ,
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Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap
By:
InVivo Biosystems ,
While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease,
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CRISPR technologies enable humanized animal models to aid disease research
By:
InVivo Biosystems ,
C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of
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Arg…What’s up with that? Arginine is Enriched in Pathogenic Variants
By:
Chris Hopkins ,
Our CSO explores a theory he has about the amino acid arginine which seems to be showing frequent association with pathogenicity.
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Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead
By:
Janis Weeks, Ph.D. ,
Neurotoxin exposure is implicated in the etiology of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease and ALS (amyotrophic lateral sclerosis). Traditionally, vertebrate animals such as
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Bayer and NemaMetrix present C. elegans results at Parasitic Helminths conference in Greece
By:
Janis Weeks, Ph.D. ,
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
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Hurricanes and Heartworms; Extreme Weather Events Spread Worms
By:
Janis Weeks, Ph.D. ,
How are extreme weather events, such as Hurricane Katrina, spreading heartworms and other parasitic nematodes and what are the implications of their spread?
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The Evolution of Drug Resistance; an Issue of “When, not if”
By:
Janis Weeks, Ph.D. ,
Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal
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Total Domination – Uncovering the Phenomenon of 1:2 Dominant vs Recessive ratio for Variation in the Genome
By:
Chris Hopkins ,
Our CSO revisits his Veritas Genomic Sequencing report for a closer look at how significant some of the discovered variants are
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A New Approach to Anti-Aging Research
By:
Yoanne Clovis, Ph.D. ,
The shift towards preventive medicine has given anti-aging startups a favorable environment in pursuing longevity and aging issues. The nematode C. elegans has emerged to
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Worming into Relevance – How C. elegans Can Help us Understand Human Health
By:
Yoanne Clovis, Ph.D. ,
Animal testing in the research-based pharmaceutical industry has been reduced in recent years both for ethical and cost reasons. However, it is still a staple
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Genomic baggage – What are the skeletons rattling in your genetic closet?
By:
Chris Hopkins ,
When you receive your genomic report, you have a movement of trepidation.What will it say? Will it have something that says you should do countermeasures
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What Can Zebrafish Tell us About CRISPR Off-Target Activity?
By:
InVivo Biosystems ,
In 2017, a now-redacted paper published in Nature Methods claimed that CRISPR created hundreds of unintended mutations in mouse models, and that algorithms designed to
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The Humanized Worm [Infographic]
By:
Anna Malinkevich, MS ,
Humanized model organisms are powerful biological models that allow scientists to study human disease genes in simpler contexts without losing the value of in vivo
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The Unnecessary Procedure – A Problem with False Positives in Genomic Testing
By:
Chris Hopkins ,
There is a significant pressure to increase diagnostic yield and it has its consequences. BRCA testing is probably the most developed ecosystem for genetic tests
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Using C. elegans to study parasitism
By:
Ramesh Ratnappan ,
C. elegans is one of the most powerful model organisms and has been used to unravel several key genetic pathways. The C. elegans nematode has been used
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Child Neurology Meeting: Bernard Sachs Award to William B. Dobyns and Precision Medicine in Epilepsy Lecture
By:
Chris Hopkins ,
The Child Neurology Society honored William (Bill) Dobyns for his highly impactful efforts in characterizing child neurology. In a prolific and highly influential carrier, Bill
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Explosive Growth of Gene Variant Numbers
By:
Chris Hopkins ,
Genetic Testing Clinical geneticists have an acute need to understand pathogenicity in genomes of their patients (Figure 1). Cost per human genome has now approached
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Systems for Improving Diagnostic Yield of Genomic Sequence Analysis
By:
Chris Hopkins ,
How to better understanding Variants of Uncertain Significance in epilepsy and help find new therapeutic approaches Did you know that 1 in 26 people will
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A New Era of Transgenics in Parasitic Nematodes
By:
Ramesh Ratnappan ,
One of the most commonly known nematodes in the scientific community is Caenorhabditis elegans. Ever since Sydney Brenner introduced it as a model organism to
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C. elegans as Fast and Affordable System for Variant Phenotyping
By:
Chris Hopkins ,
Systems for Functional Studies A variety of modeling systems can be used to explore variant function. Initially, many researchers turn to a computational approach to
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Worming into Relevance – Human disease models in the C. elegans nematode
By:
Chris Hopkins ,
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
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KCNQ2 epilepsy gene
Functional analysis of variants to aid understanding of children’s epilepsy
By:
InVivo Biosystems ,
Performing sequence analysis on a patient with a suspected genetic disease is becoming a standard of care. However, when a genetic variation is identified as
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KCNQ2 Cures Summit – Patient Family Passion and Involvement
By:
Chris Hopkins ,
The passion to find answers is inspiring. I had the good fortune to attend the KCNQ2 Cure Summit 2018. Meeting the patient families and seeing
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Worming into Relevance – Human disease models in the C. elegans nematode
By:
Chris Hopkins ,
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
READ MORE
Properties of Top 20 Epilepsy Genes
By:
Chris Hopkins ,
Epilepsy Genetics 1 out of 100 persons is living with active epilepsy (Zack and Kobau 2017, WHO 2018). For the subset that can be pinned
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DD News features NemaMetrix in its latest issue on Animal Models of Disease
By:
InVivo Biosystems ,
The latest issue of Drug Discovery News (DDNews) features a special report on Animal Models of Disease, highlighting the NemaMetrix/Knudra merger and the value of
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Dr. Andy Golden
Unlocking the Potential of C. elegans for the Study of Rare Disease
By:
InVivo Biosystems ,
Dr. Andy Golden at NIH discusses his work on identifying regulators and interactors of conserved genes in C. elegans that, when mutated, can cause human disease
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Scientists study how cancer spreads by recording a time-lapse of C. elegans
By:
Matt Beaudet, CEO ,
Scientists from Duke University captured the cellular break-ins in C. elegans, a transparent worm that’s often used as a model for human biology. The cellular
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C. elegans in cancer research
By:
Yoanne Clovis, Ph.D. ,
In recent years, the nematode C. elegans has emerged as a model for systematic dissection of the molecular basis of tumorigenesis. Many cancer genes and
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