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Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap

Animal Model, C. elegans, Clinical Avatar, Disease Modeling, Drug Discovery, Zebrafish / By / December 17, 2019

While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease, the pace of advancing new treatments for those diseases has lagged behind significantly. One way to shorten the time between laboratory discoveries and available new drugs is to use animal …

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CRISPR technologies enable humanized animal models to aid disease research

Animal Model, C. elegans, Clinical Avatar, Disease Modeling / By / November 14, 2019

C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of which the genome has been sequenced completely [1]. One surprising result of this approach was that ~65% of the human disease genes have a counterpart in the worm [2]. In …

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Reviewers’ Choice Abstract Award at ASHG Goes to Ben Jusilla for Demonstrating how Zebrafish Can be Used for Disease Modeling

Animal Model, Disease Modeling, Zebrafish / By / October 17, 2019

Ben Jusilla, one of our in-house zebrafish experts, presented his poster “Zebrafish modeling for the clinic: Rapid in vivo functional testing of patient variants for clinical applications” at ASHG and won the Reviewers’ Choice Award in the category of Precision Medicine, Pharmacogenomics, and Genetic Therapies. His poster discusses how we use zebrafish as an in-vivo model to measure …

Reviewers’ Choice Abstract Award at ASHG Goes to Ben Jusilla for Demonstrating how Zebrafish Can be Used for Disease Modeling Read More »

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