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Reliable Antioxidant Capacity Study For Compound Efficacy Testing

Invivo Biosystems specializes in evaluating antioxidant properties in compounds and formulations. Our exclusive ROS exposure assay allows us to evaluate your products’ ability to combat reactive oxygen species (ROS). Our team of experienced scientists guarantees accurate and reliable antioxidant evaluation results so that you can make informed decisions about your compounds.

At InVivo, we specialize in uncovering antioxidant properties in compounds and formulations. Our proprietary ROS exposure assay allows us to assess the potential of your products in combating reactive oxygen species (ROS) – those damaging molecules that harm DNA, RNA, and proteins, leading to cell death. With years of expertise in the field, we are the leading authority on antioxidant evaluation. Our team of experienced scientists ensures accurate and reliable results, giving you the confidence to make informed decisions about your compounds and their potential applications.

What is Our ROS Exposure Assay?

Our ROS Exposure Assay follows systematic steps to assess the antioxidant potential of your compounds or formulations.

  • Compound Pre-treatment: Animals are pre-treated with your compounds to ensure accurate representation and evaluation of their antioxidant properties.

  • Exposure to Oxidizing Hazardous Chemicals: The pre-treated animals are then exposed to oxidizing hazardous chemicals, simulating oxidative stress conditions.

  • Continuous Monitoring: We carefully observe and monitor the health and movement of the animals over a specific period, gathering comprehensive data on antioxidant activity.

  • Activity Curve: We present a clear and informative curve that showcases the antioxidant activity over time after the application of the oxidizing chemical. This graphical representation helps you visualize the effectiveness of your compounds.

  • Descriptive Statistics and Group Comparisons: Rigorous descriptive statistics and tests are performed to identify any significant differences between groups. This thorough analysis substantiates the antioxidant properties of your compounds with scientific validation.

  • Our exclusive ROS Exposure Assay is best suited for researchers, pharmaceutical companies, and product developers seeking to uncover and substantiate antioxidant properties in their compounds.

See how we help our clients with pre-clinical studies.

Fig A & B: Resistance to oxidative stress. Compound A
conferred resistance to the Reactive Oxygen Species
produced after exposure to the pesticide Paraquat.
Oxidative resistance due to Compound A treatment
was better than the Vitamin C positive control.

Service Offerings

Data Only

Data Interpretation

Data Customization

FAQs for Antioxidant Capacity Study

Total antioxidant capacity is a crucial parameter in evaluating the overall ability of a substance or sample to neutralize harmful reactive oxygen species (ROS) and prevent oxidative damage. This capacity serves as an essential indicator of the substance's potential to combat oxidative stress, which is associated with various diseases and aging processes. Understanding the total antioxidant capacity of a compound or formulation helps researchers, pharmaceutical companies, and health practitioners in identifying potent antioxidants for therapeutic purposes and developing antioxidant-rich products to promote overall well-being.

While antioxidant activity and antioxidant capacity both relate to the ability to counteract oxidative stress, they represent distinct aspects of antioxidant evaluation. Antioxidant activity typically focuses on examining the specific effects of antioxidants on particular oxidative reactions, often in vitro or cellular models. This analysis provides insight into the direct interactions between antioxidants and reactive oxygen species.

On the other hand, antioxidant capacity encompasses a broader assessment of the overall antioxidant potential of a substance. It considers the cumulative ability to neutralize various types of ROS and protect against oxidative damage over a defined period. Antioxidant capacity assays are more comprehensive and provide a holistic understanding of how effective a substance is in combating oxidative stress under diverse conditions.

The antioxidant capacity study offers invaluable benefits for researchers and product developers in various fields. Understanding the antioxidant capacity of compounds and formulations allows for:

  • Optimized Therapeutic Agents
  • Enhanced Product Development
  • Scientific Validation
  • Healthier Lifestyle Choices

Antioxidant species are composed of three categories, namely:

  • Enzymatic Antioxidants: These are antioxidant enzymes that play a vital role in neutralizing reactive oxygen species (ROS) and other free radicals. Examples include superoxide dismutase (SOD), catalase, and glutathione peroxidase. Enzymatic antioxidants are produced by the body and are essential for maintaining the cellular redox balance.
  • Non-Enzymatic Antioxidants: Non-enzymatic antioxidants are small molecules that can scavenge and neutralize ROS. These antioxidants are obtained from dietary sources or can be synthesized within the body. Examples include vitamins C and E, glutathione, carotenoids, and flavonoids.
  • Metal Binding Proteins: Metal binding proteins are a unique class of antioxidants that help regulate metal ions, particularly transition metal ions like iron and copper, which can catalyze the formation of harmful free radicals. Metal binding proteins, such as ferritin and metallothionein, sequester and stabilize these metal ions, reducing their potential to promote oxidative damage.

Yes, we offer custom injection services where you provide the gene editing idea in your strain receive professionally prepared injection mix containing all of the required molecular components to achieve your desired custom genetic edit. You will, however, require access to microinjection rig, technical skills for proper injection, and the ability to screen and select final desired strain(s).

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