C. elegans - the best non-vertebrate model for aging and longevity study
Aging is a complex biological process characterized by degenerative changes that progressively diminish function, leading to disease, and ultimately, death. Since it has long been a concern, the research of aging involved in gene expression and multiple pathways has been widely studied and reported. Due to the experimental challenges of studying aging in humans or other vertebrates are substantial, the easy-culturing nematode C. elegans is an excellent model system for studies of aging based on the identification of mutations, drugs, and environmental factors that extend the adult lifespan significantly. We offer a variety phenotypic measurements of age-associated changes that serve as biomarkers indicative of the physiological status of aging to provide information for aging research.
The nematode C. elegans is a powerful experimental organism for the implementation of a vast array of technologies and applied in much biological research. Unlike other single-celled organisms, such as bacteria and yeast, the millimeter-long body of C. elegans contains muscles, nerves, sexual organs, and guts, and has brought a wealth of information at the cellular level. It reacts to different environments and exhibits different responses.
InVivo Biosystems offers a series of thoughtful age-related phenotypic screening services, including lifespan and healthspan testing , age-related morphological detection, age-related behavioral detection, reproductive capacity analysis.
Effects of Drugs on Aging
Predict the acute and long term effects of your compound on the ageing organism before clinical trial.
We provide the measurements of behavior and systemic changes that occur during the agin process in a live animal model.
Effects of Genetic Variants on Aging
Rapidly uncover the effects of your genetic modifications on healthspan and life expectancy using a simple animal model.
We provide analysis of behavioral and systemic changes that occur during the aging in a controlled genetic context.
Effects of Drugs on Neuromuscular Activity
Predict the acute and long term effects of your compound on neuromuscular activity.
We provide measurements of the neuromuscular changes that occur as a result of exposure to your compound.
Effects of Genetic Variants on Neuromuscular Activity
Predict the effects of the genetic changes of your choice on neuromuscular activity.
We provide assessment of the neuromuscular function under the genetic control of your choice.
We focus on early in-vivo testing using relevant and time-efficient whole animal models so you can shorten your project timeline. In preclinical stage, we help you kickstart your research by testing your hypothesis or conducting proof of concept before you move to a more complex and costly model system. Using our platform, you can quickly and economically test a compound’s ability to extend lifespan and healthspan with large sample sizes of live animals in 2-3 months.
Automatically Quantify Longevity And Healthspan
InVivo Biosystems’ longevity platform tracks C. elegans movement throughout their lives. Both lifespan and healthspan are measured every 15 minutes. (Left): Animals’ movement. Color purple: animals are healthy; color yellow: animals are unhealthy; color red: animals are dead. (Right): percent of population alive.
Advanced Aging Pathway Analysis.
We can identify the pathways that contribute to the observed lifespan extension using RNA-Seq or whole transcriptome sequencing (WTS). For example, we can identify the anti-aging pathways that contribute to the observed lifespan extension from the lifespan analysis.