The ability to quickly install variant alleles in C. elegans and zebrafish, and quantitatively measure the variant phenotypes provides researchers a path to rapidly address the consequence of gene variation for answering questions of neurodegenerative disease biology.
The images below illustrate C. elegans as a transgenic model for studying gene variations associated with Alzheimer’s Disease (AD), Frontotemporal Dementia (FD), and Epilepsy Disorder (ED).
We have preselected disease-relevant models and validated their genetic identity with PCR and sequencing. These humanized model systems can serve as another efficient tool set to study human diseases.
Strains carrying genetic mutations that are associated with Alzheimer’s disease, validated via PCR and sequencing.
Models carrying genetic mutations that are associated with Epilepsy disorder, validated via PCR and sequencing.
We can create other neurodegenerative disease-relevant models using zebrafish and C. elegans, including Frontotemporal Degeneration and Huntington’s diseases.