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The ability to quickly install variant alleles in C. elegans and zebrafish, and quantitatively measure the variant phenotypes provides researchers a path to rapidly address the consequence of gene variation for answering questions of neurodegenerative disease biology.
The images below illustrate C. elegans as a transgenic model for studying gene variations associated with Alzheimer’s Disease (AD), Frontotemporal Dementia (FD), and Epilepsy Disorder (ED).
Testing new compounds and formulations to understand whether they are functionally effective on disease phenotypes.
Green Text: ED human genes expressed with worm gene homologue (in parentheses).
We have preselected disease-relevant models and validated their genetic identity with PCR and sequencing. These humanized model systems can serve as another efficient tool set to study human diseases.
Strains carrying genetic mutations that are associated with Alzheimer’s disease, validated via PCR and sequencing.
Models carrying genetic mutations that are associated with Epilepsy disorder, validated via PCR and sequencing.
We can create other neurodegenerative disease-relevant models using zebrafish and C. elegans, including Frontotemporal Degeneration and Huntington’s diseases.
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An expert in CRISPR genome editing, InVivo Biosystems creates custom genome-edited C. elegans and zebrafish models to enable aging, developmental, and disease studies. Our unique in vivo platforms and technologies bridge the gap between cells and mice.