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Neurodegenerative Disease Models

Preselected Neurodegenerative Disease-Relevant Models

The ability to quickly install variant alleles in C. elegans and zebrafish, and quantitatively measure the variant phenotypes provides researchers a path to rapidly address the consequence of gene variation for answering questions of neurodegenerative disease biology.

The images below illustrate C. elegans as a transgenic model for studying gene variations associated with Alzheimer’s Disease (AD), Frontotemporal Dementia (FD), and Epilepsy Disorder (ED).

C. elegans as a transgenic model for studying Alzheimer’s Disease (AD) and Frontotemporal Dementia (FD).

Testing new compounds and formulations to understand whether they are functionally effective on disease phenotypes.

C. elegans as a transgenic model for studying Epilepsy Disorder (ED).

Green Text: ED human genes expressed with worm gene homologue (in parentheses).

Featured Offerings

We have preselected disease-relevant models and validated their genetic identity with PCR and sequencing. These humanized model systems can serve as another efficient tool set to study human diseases.

Models for Alzheimer’s Disease | InVivo Biosystems

Models for Alzheimer’s Disease

Strains carrying genetic mutations that are associated with Alzheimer’s disease, validated via PCR and sequencing.

Models for Epilepsy Disorder | InVivo Biosystems

Models for Epilepsy Disorder

Models carrying genetic mutations that are associated with Epilepsy disorder, validated via PCR and sequencing.

Other Offerings

We can create other neurodegenerative disease-relevant models using zebrafish and C. elegans, including Frontotemporal Degeneration and Huntington’s diseases.

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