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Genetic pathways can be up or down regulated as a result of exposure to different compounds. We can determine how a compound or formulation affects gene expression using RNAseq and transcriptomics technology. We then condense this information, giving you specific guidance on what endpoints to evaluate in clinical studies.
Expose animals to compounds or formulation
Evaluate the expression levels of all genes
Analysis of up and down regulated genes.
KEGG and GO analysis of genetic pathways that are impacted by compounds.
Guiding human clinical studies
Indication expansion
Summary of pathway mapping to established aging-related pathways for Compound A treatment in aged (Day 10) animals. Colored score increments indicate the change of expression, up-regulated (red) or down-regulated (blue), weighted by the P value.
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An expert in CRISPR genome editing, InVivo Biosystems creates custom genome-edited C. elegans and zebrafish models to enable aging, developmental, and disease studies. Our unique in vivo platforms and technologies bridge the gap between cells and mice.