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state of knock-ins in zebrafish

The State of Knock-ins in Zebrafish

The recent advancements of CRISPR and next-generation technology has enabled researchers to create more precise zebrafish models of human disease. This being said, knock-in (KI) techniques in zebrafish still aren’t fully optimized. In this article we discuss the current state of CRISPR-Cas9-mediated targeted knock-ins in zebrafish, and what the future holds.

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RedEfish: Generation of the Polycistronic mScarlet: GSG-T2A: Ttpa Zebrafish Line

RedEfish: Generation of the Polycistronic mScarlet: GSG-T2A: Ttpa Zebrafish Line

Dr. Robyn Tanguay is a distinguished professor at Oregon State University, and a collaborator with InVivio Biosystems. Dr. Tangauy utilizes zebrafish to study toxicology, and last month received a $7 million grant from the National Institute of Environmental Health Sciences to study the biological impacts of chemicals. In a recent publication, Dr. Tanguay and her lab created a new fluorescent-tagged zebrafish line to study the effects of Vitamin E on embryonic development. This article will give an overview of the Tanguay Lab’s work, and discuss: ‘why zebrafish’?

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We Used CRISPR to Make 15 Point Mutations in 5 Genes. Here’s What We Learned.

You may or may not know that at InVivo Biosystems, we conduct a lot of grant funded research as well as offering custom models and assays to our clients. Much of our grant activity in the past few years has centered on creating and characterizing disease-associated variants and point mutations. We’ve created collaborations and partnerships …

We Used CRISPR to Make 15 Point Mutations in 5 Genes. Here’s What We Learned. Read More »

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