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InVivo Biosystems Blog

Category: Gene Editing

Cas9 or Cas12a? Benefits of Expanding Your Gene Editing Toolbox
By:
Ally Wimberly ,
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Preclinical Drug Discovery | InVivo Biosystems
Biological Quality Control Assay Validation Services
By:
Ally Wimberly ,
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CRISPR ZEBRAFISH KNOCKIN | InVivo Biosystems
Modeling Anxiety and Stress in Zebrafish: Thigmotaxis
By:
Ally Wimberly ,
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Zebrafish vs. Mouse Models: A New Standard in Behavioral Assays
By:
Ally Wimberly ,
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Rapid Results: The RapidGen™ CRISPR Approach
By:
Ally Wimberly ,
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Using Zebrafish to Combat Cognitive Decline: How a Biopharmaceutical Company Leveraged a Zebrafish Model to characterize a Compound for Neurodegenerative Disease Therapeutics
By:
Alexandra Narin ,
Joseph Bruckner ,
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Speeding up the diagnostic journey for Rare Disease patients: An in vivo discovery platform that helps classify variants of uncertain significance
By:
Chris Hopkins ,
Alexandra Narin ,
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feature image for humanized customer story updates
A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia [Where are they now: Customer Story]
By:
Alexandra Narin ,
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WHAM with CRISPR - re-imaging how rare disease therapeutics are developed
Whole-gene Humanized Animal Models (WHAM) with CRISPR – Re-imagining how Rare Disease therapeutics are developed
By:
Chris Hopkins ,
Alexandra Narin ,
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America is finally investing in Biotechnology & Biomanufacturing in a Big Way
By:
Alexandra Narin ,
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Looking at Gene Paralogs across both zebrafish and C. elegans Model Organisms [Customer Story]
By:
Alexandra Narin ,
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Review: How a Small Worm is Helping Uncover the Pathogenicity of Gene Variants
By:
Ben Jussila ,
Alexandra Narin ,
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Differences Between HDR vs NHEJ
By:
Chesley Johnson ,
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How Do Knockins Work?
By:
Karl Stuntzner-Gibson ,
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The ABCs of Genetic Research
By:
Alexandra Narin ,
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The State of Knock-ins in Zebrafish
By:
Alexandra Narin ,
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RedEfish: Generation Of The Polycistronic MScarlet: GSG-T2A: Ttpa Zebrafish Line
By:
Alexandra Narin ,
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A Spotlight on Recent Zebrafish Research
By:
Ben Jussila ,
We’ve compiled some of the most recent informative and influential research being done using the zebrafish model
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How do I get rid of this pesky protein? The Hows and Whys of Protein Degradation
By:
Trisha Brock ,
Being able to understand how a protein acts in specific tissues and times can be key for the general understanding of a protein’s function.
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How to identify a successful transgenic edit in C. elegans Part 1
By:
Lauren Resch ,
In this blog, we will discuss key factors to consider when choosing a screening method, introduce various editing techniques, and discuss the pros & cons
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90 Mutations with 1 Gene: Functional Analysis of Variants Using C. elegans
By:
Trisha Brock ,
Kathryn McCormick ,
We created over 90 point mutations in the STXBP1 gene via CRISPR. A map of these point mutations can be seen above. Clinical variants were
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PCR Vs. HRMA For Genotyping: When To Use What?
By:
Preston Kendrick ,
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Fluorescent Tagging Capability Demonstration
By:
Lauren Resch ,
At InVivo Biosystems, we have been working with fluorescent tags in C. elegans for over five years, and we have made over 600 fluorescent transgenic
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We Used CRISPR To Make 15 Point Mutations In 5 Genes. Here’s What We Learned.
By:
Trisha Brock ,
Kathryn McCormick ,
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Zebrafish Injection Mix: Buy verses DIY, what are the real costs? [Infographic]
By:
InVivo Biosystems ,
Make sure you understand all of the costs associated with DIY-ing a zebrafish CRISPR project verses outsourcing it to a team with years of experience.
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Precise Knock-Outs For Precise Research
By:
Lauren Resch ,
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11 Steps to a Successful CRISPR Knock-in
By:
Trisha Brock ,
Knock-ins are hard, for a long time people even said they were impossible, but we are nearing an 80% success rate for CRISPR knock-ins in
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The Challenge of Getting CRISPR-based Knock-ins to Work in Zebrafish
By:
Chris Hopkins ,
Kathryn McCormick ,
We take a look into why so many zebrafish groups struggle to achieve knock-in transgenesis and what makes knock-ins so difficult.
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6 Things That Can Go Wrong While Making Your Zebrafish CRISPR Knock-In
By:
Ben Jussila ,
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To truly validate your sgRNAs, go In Vivo
By:
Marnie Preston ,
CRISPR/Cas9 gene editing for Zebrafish is a rapidly growing molecular biology toolset with diverse applications, but is not without its technological barriers. Reagent sourcing, design
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CRISPR technologies enable humanized animal models to aid disease research
By:
InVivo Biosystems ,
C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of
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Arg…What’s up with that? Arginine is Enriched in Pathogenic Variants
By:
Chris Hopkins ,
Our CSO explores a theory he has about the amino acid arginine which seems to be showing frequent association with pathogenicity.
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Article Review: The Caenorhabditis elegans Transgenic Toolbox
By:
Sophia Bethel ,
We reviewed a recent article that discusses the best techniques available for C. elegans transgenics, as well as experimental concerns that should be considered.
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Genomic baggage – What are the skeletons rattling in your genetic closet?
By:
Chris Hopkins ,
When you receive your genomic report, you have a movement of trepidation.What will it say? Will it have something that says you should do countermeasures
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Conditional mutagenesis by loxP insertion in zebrafish – outfoxing the unfloxable
By:
Ben Jussila ,
CRISPR/Cas9-mediated integration of loxP sequences for conditional mutagenesis in zebrafish has recently made its way into the toolkit of zebrafish researchers. In particular, CRISPR/Cas9 mutagenesis
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The Humanized Worm [Infographic]
By:
Ally Wimberly ,
Humanized model organisms are powerful biological models that allow scientists to study human disease genes in simpler contexts without losing the value of in vivo
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New Milestone! We can now remove over 43,000 bp from C. elegans genomic DNA!
By:
Yoanne Clovis, Ph.D. ,
12k, 24k, 36k…we can now precisely remove over 43k bp from C. elegans genomic DNA! Knocking out genes is a commonly used tool for biologists
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C. elegans as Fast and Affordable System for Variant Phenotyping
By:
Chris Hopkins ,
Systems for Functional Studies A variety of modeling systems can be used to explore variant function. Initially, many researchers turn to a computational approach to
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Worming into Relevance – Human disease models in the C. elegans nematode
By:
Chris Hopkins ,
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
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KCNQ2 epilepsy gene
Functional analysis of variants to aid understanding of children’s epilepsy
By:
InVivo Biosystems ,
Performing sequence analysis on a patient with a suspected genetic disease is becoming a standard of care. However, when a genetic variation is identified as
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Worming into Relevance – Human disease models in the C. elegans nematode
By:
Chris Hopkins ,
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
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CRISPR/Cas9 off target effects: Hyperactive cutting or media hype?
By:
Ben Jussila ,
There has been a lot of media coverage in recent months surrounding CRISPR/Cas9 and the potentially life changing impact the gene-editing technology could have. More
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Insertion of two loxP sites to produce a knockout (KO) of an embryonic lethal gene
By:
Trisha Brock ,
A client wanted a knockout (KO) of an embryonic lethal gene. We could not make this line using our standard methods. Instead, we inserted two
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An Abnormal Absence of Antibodies: Filling the Gaps with Gene Editing Tools in Zebrafish
By:
Ben Jussila ,
The zebrafish is an increasingly popular laboratory organism with many experimental advantages. The animal model has been used by biologists to discover the detailed processes
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Genome wide associations and the nematode pharynx: ever the twain shall meet
By:
Shawn Lockery, Ph.D., Co-founder ,
Question: What might you get if you cross the feeding organ of a roundworm with a genome wide association study? Answer: A cornucopia of novel
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Dr. Andy Golden
Unlocking the Potential of C. elegans for the Study of Rare Disease
By:
InVivo Biosystems ,
Dr. Andy Golden at NIH discusses his work on identifying regulators and interactors of conserved genes in C. elegans that, when mutated, can cause human
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Modeling Rare Diseases in Caenorhabditis elegans
By:
Shawn Lockery, Ph.D., Co-founder ,
There are approximately 7,000 rare diseases in humans, ~80% of which are monogenic. A rare disease is defined as affecting less than one in 1,500
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The cerebellum of a brain affected by Niemann-Pick Type C; blue staining shows the dense pockets of lipid accumulations throughout the brain
Searching for a cure for Niemann-Pick Type C using C. elegans
By:
Terra Hiebert, Ph.D. ,
Yoanne Clovis, Ph.D. ,
Niemann-Pick Type C is a rare and fatal disorder affecting children. We explore the efficacy of new potential therapeutics with the ScreenChip System.
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