One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.
Aging & Healthspan
June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking place in alternative animal models: C. elegans: Kumar DK, Choi SH, Washicosky KJ, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci …
Learn more about our Longevity Platform and how it can benefit you by tuning into our recent webinar! Title: A Shortcut to Understanding Longevity: A Rapid in vivo Analysis of a Compound’s Effect on Health and Aging Agenda: Who are we? Healthy Aging: compounds for improving longevity and healthspan Nutraceutical market drivers and pain points InVivo …
NemaMetrix is the market leader for early preclinical in-vivo testing using small animal models to gain a better understanding of the efficacy, mode of action, toxicity and potential targets for novel compounds. In this case study we outline how we used the animal model C. elegans to perform a set of specific experiments designed by our experts to provide rapid and reliable data based on our customer’s priorities. Using the data that we provided, our customer was able to apply for multiple patents in a timely manner.
The shift towards preventive medicine has given anti-aging startups a favorable environment in pursuing longevity and aging issues. The nematode C. elegans has emerged to be a useful animal model for anti-aging and longevity studies.
Interesting data using C. elegans for studying the impact your gut microbiome may have on your lifespan and healthspan from the Wang Lab at Baylor College of Medicine. The study highlights the power of C. elegans as a tool for whole animal discovery – the work would have been impossible to carry out using cultured cells and would have been prohibitively expensive in mice.
C. elegans’ feeding behavior strongly influences the worm’s aging and longevity. We tested adult worms to quantify how aging affects their feeding behavior. In older adults, pharyngeal pumping was weaker and less regular.