Zebrafish Toxicity Testing

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Why Use Zebrafish?


Mammalian and zebrafish toxicity profiles are strikingly similar. Zebrafish organs are similar to human in cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate organ-specific diseases.

Many genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of organ-specific diseases, such as heart, liver or neurological disorders.

Time Saving:

Zebrafish develop rapidly; all of their major organ systems become fully formed during the early larval stages, making it a recognized standard model to assess organ toxicity.

Even at an early stage, zebrafish show concordance at a metabolic pathway level, confirming its utility as a model to screen the toxic potential of compounds on major organs*.

For instance, zebrafish are comparable with a mammalian model: 94% of chemicals that were toxic in rat embroys could have also been shown to be toxic in zfish embroys (link from below). 

our offerings

The InVivo Biosystems Technology provides the deep insights you need to make a go/no-go decision. Our data analysis and focused team of experts will also help you understand the results and identify the next steps.

Hepatotoxicity Testing

Determine whether a compound or formulation induces liver damage. Measurements using early life-stage zebrafish include gross tissue health, necrosis, liver function and cell death.

Neurotoxicity Testing

Assess whether a compound or formulation induces nervous system damage. Early life-stage zebrafish will be used to measure neural gene expression via qPCR.

Cardiotoxicity Testing

Assess whether a compound or formulation induces heart damage in zebrafish. Early life-stage zebrafish will be used to assess cardiac function.

Other offerings

Embryo Acute Toxicity Test

Determine the acute or lethal toxicity of chemicals on embryonic stages of fish (Danio rerio).

Early-life Stage Toxicity Test

Determine the lethal and sub-lethal effects of chemicals on the early life stages of the fish.

Zebrafish Behavioral Phenotyping

Assess photomotor response, measure anxiety behaviors, or understand learning and memory mechanisms.

Our Process


Understand Your Goal

We will set up a 30-minute call with you to understand your needs. During this call, we will define the scope of your project, answer your practical questions and help you assess whether our service is a good fit for you.




Create A Custom Catalog

After we decide on the scope of the project, we will create a proposal that includes cost and time estimate for each experiment proposed. You will be able to personalize your project plan.


Finalize Project Design

We will send you a final statement of work and payment schedule. Once we receive your first PO, we will start the experiments and give you a defined timeline for your project.


Report Out

Maintain Clarity And Transparency

We will keep you updated every two weeks on the status of your project. At the end of your project, we provide you with a report that includes comprehensive findings and key takeaways.


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