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Many genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of organ-specific diseases, such as heart, liver or neurological disorders.
Zebrafish develop rapidly; all of their major organ systems become fully formed during the early larval stages, making it a recognized standard model to assess organ toxicity.
Even at an early stage, zebrafish show concordance at a metabolic pathway level, confirming its utility as a model to screen the toxic potential of compounds on major organs*.
For instance, zebrafish are comparable with a mammalian model: 94% of chemicals that were toxic in rat embroys could have also been shown to be toxic in zfish embroys (link from below).
The InVivo Biosystems Technology provides the deep insights you need to make a go/no-go decision. Our data analysis and focused team of experts will also help you understand the results and identify the next steps.
Determine whether a compound or formulation induces liver damage. Measurements using early life-stage zebrafish include gross tissue health, necrosis, liver function and cell death.
Assess whether a compound or formulation induces nervous system damage. Early life-stage zebrafish will be used to measure neural gene expression via qPCR.
Assess whether a compound or formulation induces heart damage in zebrafish. Early life-stage zebrafish will be used to assess cardiac function.
Determine the acute or lethal toxicity of chemicals on embryonic stages of fish (Danio rerio).
Determine the lethal and sub-lethal effects of chemicals on the early life stages of the fish.
Assess photomotor response, measure anxiety behaviors, or understand learning and memory mechanisms.
We will set up a 30-minute call with you to understand your needs. During this call, we will define the scope of your project, answer your practical questions and help you assess whether our service is a good fit for you.
After we decide on the scope of the project, we will create a proposal that includes cost and time estimate for each experiment proposed. You will be able to personalize your project plan.
We will send you a final statement of work and payment schedule. Once we receive your first PO, we will start the experiments and give you a defined timeline for your project.
We will keep you updated every two weeks on the status of your project. At the end of your project, we provide you with a report that includes comprehensive findings and key takeaways.
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An expert in CRISPR genome editing, InVivo Biosystems creates custom genome-edited C. elegans and zebrafish models to enable aging, developmental, and disease studies. Our unique in vivo platforms and technologies bridge the gap between cells and mice.