Many genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of organ-specific diseases, such as heart, liver or neurological disorders.
Zebrafish develop rapidly; all of their major organ systems become fully formed during the early larval stages, making it a recognized standard model to assess organ toxicity.
Even at an early stage, zebrafish show concordance at a metabolic pathway level, confirming its utility as a model to screen the toxic potential of compounds on major organs*.
For instance, zebrafish are comparable with a mammalian model: 94% of chemicals that were toxic in rat embroys could have also been shown to be toxic in zfish embroys (link from below).
The InVivo Biosystems Technology provides the deep insights you need to make a go/no-go decision. Our data analysis and focused team of experts will also help you understand the results and identify the next steps.
Determine whether a compound or formulation induces liver damage. Measurements using early life-stage zebrafish include gross tissue health, necrosis, liver function and cell death.
Assess whether a compound or formulation induces nervous system damage. Early life-stage zebrafish will be used to measure neural gene expression via qPCR.
Assess whether a compound or formulation induces heart damage in zebrafish. Early life-stage zebrafish will be used to assess cardiac function.
Determine the acute or lethal toxicity of chemicals on embryonic stages of fish (Danio rerio).
Determine the lethal and sub-lethal effects of chemicals on the early life stages of the fish.
Assess photomotor response, measure anxiety behaviors, or understand learning and memory mechanisms.