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InVivo Biosystems Blog

Category: Drug Discovery

Leaky gut assays feature image

Leaky Gut Assays in Animal Models

By:
Alexandra Narin ,
Chris Hopkins ,
Inflammation in your intestine is detrimental to overall health, and can create many complications. So how is this phenomenon researched?
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No animals, new drugs, no problem

New drugs, No Animals, No Problem. The FDA announced legislative changes – drugs are no longer required to be tested in animals before moving to human trials. What does that mean?

By:
Alexandra Narin ,
The FDA announced animal testing no longer necessary for drug discovery. In this article we discuss the implications for USA’s drug pipeline.
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WHAM with CRISPR - re-imaging how rare disease therapeutics are developed

Whole-gene Humanized Animal Models (WHAM) with CRISPR – Re-imagining how Rare Disease therapeutics are developed

By:
Chris Hopkins ,
Alexandra Narin ,
Traditional modeling of patient variants in vivo has two limitations which can be overcome utilizing InVivo Biosystems’ patented WHAM-method.
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customer story: zebrafish CRO feature image

Using Zebrafish CRO to Accelerate Grant Application Process

By:
Alexandra Narin ,
Dr Quintana chose to leverage InVivo Biosystems’ fully validated custom injection mixes to create point mutations that target the protein HFC1 in zebrafish
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WHAM - humanized animal models for drug discovery

WHAMyness – How Gene-Humanized Animals Can Dramatically Improve Drug Discovery

By:
Chris Hopkins ,
Alexandra Narin ,
Current in vivo platforms are limited in their ability to identify drug candidates – Whole-gene Humanized Animal Models can help.
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America is finally investing in Biotechnology & Biomanufacturing in a Big Way

By:
Alexandra Narin ,
In this article we discuss what President Biden’s New Executive Order means for America’s place in the biotech and biomanufacturing fields.
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The Path to Affordable Therapeutics in Rare Disease – Tackling Congenital Disorder of Glycosylation in the PMM2 gene [Customer Story].

By:
Hannah Huston ,
Alexandra Narin ,
Chris Hopkins ,
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[Patent Announcement] InVivo Biosystems has officially been issued a patent on WHAM-humanization in the nematode, C. elegans

By:
Alexandra Narin ,
We are excited to announce that the USPTO has issued a patent titled, ‘Transgenic animal phenotyping platform and uses thereof’ to InVivo Biosystems.
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Looking at Gene Paralogs across both zebrafish and C. elegans Model Organisms [Customer Story]

By:
Alexandra Narin ,
Drs Pruyne & Almack leveraged InVivo Biosystems’ Custom Injection Mix to design and create a novel zebrafish line.
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Part Two: Is Drug Repurposing the New Model for Drug Discovery?

By:
Astha Nimavat ,
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Part One: An Overview of Drug Repurposing

By:
Astha Nimavat ,
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Chemicals Models of Parkinson’s Disease in Larval Zebrafish

By:
Laura Taggart-Murphy ,
Alexandra Narin ,
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Poking its way into Western Medicine: How Acupuncture Could Help Ease Chronic Pain

By:
Alexandra Narin ,
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A Natural Fit – Using Zebrafish to Evaluate Natural Compounds for Anti-Inflammatory Properties

By:
Laura Taggart-Murphy ,
Alexandra Narin ,
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Quick Guide to Natural Products: What They are and How They Impact You

By:
Alexandra Narin ,
Summary: This Earth Month we at InVivo Biosystems are thinking about how we utilize Earth’s resources in biomedicine – from animal systems that enable us
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microbiome models feature image

Models to Research Microbiome

By:
Alexandra Narin ,
Chris Hopkins ,
In this article, we will discuss the commonly used model organisms for microbiome research, and what insights they can provide.
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zfish as drug discovery tool feature image

Lost and Found: Zebrafish as a Drug Discovery Tool

By:
Alexandra Narin ,
Summary Zebrafish models largely began as a way to research developmental biology, however, their potential to be a preclinical model of human disease quickly became
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Neuroscience Models: Transgenic Mice, Zebrafish, C. Elegans – And Jellyfish?

By:
Alexandra Narin ,
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From ED to AD: a drug repurposing success? How a performance-enhancing drug is giving insight into dementia

By:
Alexandra Narin ,
Recently, researchers at Cleveland Clinic’s Genomic Medicine Institute published an article in Nature Aging which has caused quite a stir in the medical community and
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The In (vitro, vivo, silico)s and Outs of Research

By:
Alexandra Narin ,
Experiments fall into three categories – in vivo, in vitro, and in silico studies, and all of them have a different, but important role in
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The Discrepancy Between Sexes: Clinical Models & Clinical Trials

By:
Alexandra Narin ,
Pharmaceutical drugs go through a rigorous process that tests their safety and efficacy before gaining FDA approval and being put on the commercial market. Traditionally,
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A Closer Look at Nutraceutical Regulations: How Does the USA Compare?

By:
Alexandra Narin ,
In this article we will explore how the nutraceutical regulations compare in the USA and abroad, asking how they are defined in each country, what
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Recent Nutraceutical Research

By:
Alexandra Narin ,
We’ve rounded up some of the recent publications that we’ve been enjoying – click their links below to see what’s new in this space!
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Testing the Neuroprotective Effect of a Lead Compound Using C. elegans for Fast and Cost-Effective Answers [Customer Story]

By:
Hannah Huston ,
Alexandra Narin ,
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FDA versus FTC Approval – What is the Difference?

By:
Alexandra Narin ,
In this article we aim to clarify the intent behind these therapies and what their labelling means by asking: Why aren’t nutraceutical products FDA approved?
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HIV, COVID-19, Alzheimer’s: The Impact of The FDA’s Expedited Programs and What’s Next

By:
Alexandra Narin ,
The FDA’s emergency use authorization (EUA) of the COVID-19 vaccines has brought the approval process of vaccines and drugs into public consciousness, however, the FDA’s
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How Can a Drug Get to Market Faster? Explaining the FDA’s Expedited Drug Tracks

By:
Alexandra Narin ,
Getting a drug to market is notoriously difficult, taking 7-10 years and costing hundreds of millions of dollars. This, coupled with the Covid-19 pandemic’s impact
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New Alzheimer’s Drug: Helpful or Just Expedient?

By:
Alexandra Narin ,
Aducanumab has been plagued with controversy since it was announced. We take a look to see if it is helpful, or just expedient.
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Rising Healthcare Costs? Non-Mammalian Models To The Rescue

By:
Alexandra Narin ,
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The Application of Hypersensitivity Assays to the Discovery of Therapeutics

By:
Chris Hopkins ,
Using Humanization we can take advantage of the ancient biology between humans and other organisms to create stand-ins – patient avatars – for drug screening
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Let’s Fail Faster: Why Scientific Failures Should be Accepted as Progress

By:
Alexandra Narin ,
In the scientific community there is an emphasis on positive results: getting published, having a drug be approved, etc. However, crucial learning happens when experiments
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The DrugAge Database: Showcasing C. Elegans In Longevity Research

By:
Alexandra Narin ,
Trisha Brock ,
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Drug Repurposing for Neurological Disorders

By:
Alexandra Narin ,
Neurological disorders are extremely widespread, affecting over 1 billion people worldwide, and have debilitating effects, impacting the brain, spinal cord, cranial nerves, and peripheral nerves.
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Whole Gene Humanization for Personalized Medicine Applications

By:
Chris Hopkins ,
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for
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How to Design a Good Phenotype Based Drug Discovery Program, and Why It Matters.

By:
Kathryn McCormick ,
With the advent of the molecular biology revolution and the human genome project in the 1990s there was a historic shift toward target-based drug
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Understanding GPCRs Using Humanized C. elegans

By:
InVivo Biosystems ,
Our CSO, Dr. Chris Hopkins presented at DR. GPCR SUMMIT 2020 on why C. elegans is an ideal model to study the underlying principles of GPCRs.
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Longevity Studies Using C. elegans to Identify Potential Anti-Aging Compounds [Customer Story]

By:
InVivo Biosystems ,
Dr. Vollmer shares his experience working with us and how the Longevity Platform delivers the results he needs within his timeline and budget.
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Seventeen Minutes of Science: Viral Gene Therapies and Their Potential Use Against COVID-19

By:
InVivo Biosystems ,
Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook
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Bacteria, Protozoa And Nematodes, Oh My!: Seeking New Drugs Against COVID-19

By:
Janis Weeks, Ph.D. ,
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Seventeen Minutes of Science: Spreading out from Kendall (Episode 6)

By:
Hannah Huston ,
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[New Webinar] A Shortcut to Understanding Longevity

By:
Hannah Huston ,
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Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap

By:
InVivo Biosystems ,
While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease,
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wMicroTracker Applications: Drug Screening

By:
Yoanne Clovis, Ph.D. ,
The wMicroTracker is a great product to add to your drug screening toolkit. Check out the application sheet below to see how easy it is
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Worms, Flies or Fish? A Comparison of Common Model Organisms — Part 2: Models for human diseases

By:
Yoanne Clovis, Ph.D. ,
Non-mammalian model organisms are typically used in early research to deliver fast answers to a discovery problem. The most popular model organisms in biological and
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Worms, Flies or Fish? A Comparison of Common Model Organisms – Part 1: Models for Biomedical Research

By:
Yoanne Clovis, Ph.D. ,
Non-mammalian model organisms are typically used in early research to deliver fast answers to a discovery problem. The most popular model organisms in biological and
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Are worms the future of drug development?

By:
InVivo Biosystems ,
NemaMetrix’s ScreenChip collects live-animal, high-throughput C. elegans electropharyngeograms (EPGs), which are an indication of overall organism health for drug development. Read the blog post on BioCoder
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