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Drug Discovery

Quick Guide to Natural Products: What They are and How They Impact You

Summary: This Earth Month we at InVivo Biosystems are thinking about how we utilize Earth’s resources in biomedicine – from animal systems that enable us to model a patient’s disease or gene mutation, to natural products which can act as therapeutics, we have a lot to be grateful for.  Often when thinking about celebrating Earth …

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Lost and Found: Zebrafish as a Drug Discovery Tool

Summary Zebrafish models largely began as a way to research developmental biology, however, their potential to be a preclinical model of human disease quickly became apparent. While the pharmaceutical industry initially invested in zebrafish models, they have yet to widely adopt it – it’s time for that to change.  George Stresinger began using zebrafish as …

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From ED to AD: a drug repurposing success? How a performance-enhancing drug is giving insight into dementia

Recently, researchers at Cleveland Clinic’s Genomic Medicine Institute published an article in Nature Aging which has caused quite a stir in the medical community and media – in the article these researchers report that an analysis of over 7 million people, spanning six years, found that those taking the Erectile dysfunction (ED) drug sildenafil (marketed as Viagra) were 69% less likely to develop Alzheimer’s disease (AD). This being said, there are some important caveats to this study – and so, although media reports on this study include lines such as “the little blue pill could soon be prescribed to tackle dementia”, more realistic implications should be the takeaway (but not less exciting!).

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The Discrepancy Between Sexes: Clinical Models & Clinical Trials

Pharmaceutical drugs go through a rigorous process that tests their safety and efficacy before gaining FDA approval and being put on the commercial market. Traditionally, preclinical trials utilize mammalian models before clinical trials are performed (mammals are considered the gold standard of trials). But are these trials serving everyone? This article will discuss the pervasive inequality between the male and female sexes in drug development and what can be done about it.

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