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Alzheimer’s disease is one of the most economically and socially impactful diseases of our time. Through basic and clinical research, top genes that are mutated in Alzheimer’s disease have been identified.
However, it is complex and challenging to select the right mutants to study due to too many choices of strains and alleles (genetic models). In addition, researchers sometimes have doubts that a strain obtained from another source has not lost the mutation or undergone genetic drift.
Our goal is to create a curated, reliable library of strains that are relevant to Alzheimer’s disease. We have carefully selected:
Fig 1. Day-2 ALZ PSEN1 Knock-out live C. elegans on NGM plate.
The sel-12(ty11) mutation produces defects in vulva and neuronal development leading to a dysfunctional uterine-vulval connection and ultimately the inability to lay eggs. The worm is positioned head-down on the left and head-up on the right.