Close this search box.

Preclinical CRO Services

Preclinical Drug Discovery & Development with Zebrafish

InVivo Biosystems is a globally recognized leader in zebrafish-based, preclinical drug discovery and development. Trusted by biotech and pharmaceutical partners worldwide, we deliver cost-effective and human-relevant solutions, offering insights that transcend traditional test tube methods.

Benefits of C. elegans Genome Editing | InVivo Biosystems

Our Zebrafish CRO Services

Therapeutic Testing | InVivo Biosystems

Therapeutic Testing

Determine if a lead compound ameliorates disease phenotypes or affect important metabolites.

Genetic Target Validation | InVivo Biosystems

Genetic Target Validation

Determine if genes are involved in disease processes and make good targets for further discovery.

Library Screening | InVivo Biosystems

Library Screening

Medium throughput screen of compound libraries and biologics (up to BSL2).

ADME-Tox | InVivo Biosystems

Toxicity Screening

Perform acute embryo toxicity testing, targeted hepatotoxicity, neurotoxicity, and cardiotoxiciity analysis.

Compound Testing Services

Vitality Study | InVivo Biosystems

We perform lifetime monitoring of a large animal population to determine whether compounds and formulations affect lifespan and health span. Get data, including Kaplan-Meier survival estimates and detailed lifespan activity, in just 2-3 months.

We perform lifetime monitoring of a large population animals to determine whether compounds and formulations affect lifespan and healthspan.

Antioxidant Property Study | InVivo Biosystems

We assess compounds against Reactive Oxygen Species (ROS) damage. Through proprietary ROS exposure assays, get insights into a compound’s antioxidant efficacy in 2-3 months.

We uncover whether a compound or formulation has antioxidant properties using a standardized reactive oxygen species exposure assay.

Genetic Signature Study | InVivo Biosystems

We utilize RNAseq technology to analyze a compound’s effects on gene expression, offering insights beneficial for human clinical studies. Choose from Data Only, Interpretation, or Customization packages. Turnaround: 2-3 months.

We utilize cutting-edge RNAseq and transcriptomics technology to reveal how compounds impact gene expression by analyzing up or down-regulated genetic pathways.

Mitochondrial Function Study | InVivo Biosystems

We investigate the compound’s effect on mitochondrial health during aging using fluorescent imaging. Obtain raw images, statistics, and analyses over a 2-3 month timeframe.

We investigate the impact of a compound or formulation on mitochondrial function across the lifespan utilizing fluorescent imaging of mitochondrial structures.

Microbiome Study | InVivo Biosystems

We offer an innovative Gut Microbiome Study using zebrafish and C. elegans models, focusing on large-scale, cost-effective, and translatable research. Gain in-depth insights into microbial roles and genetic pathways in just 2-3 months, perfect for product development and patenting.

We determine the role of the underlying genetics in creating health benefits and investigate the underlying mechanisms involved in pathway.

Preclinical Drug Discovery & Development with Zebrafish Services FAQs

1. Why are zebrafish models vital for Preclinical Studies in Drug Discovery?
Zebrafish are essential in preclinical studies as they share genetic similarities with humans and have a rapid reproductive cycle. They are an ideal animal model in the drug development process for observing drug effects, potential side effects, and efficacy in the early stages of drug discovery. This integration can streamline the preclinical development and boost the drug candidate’s journey toward clinical trials.

2. How can a Contract Research Organization specializing in zebrafish enhance Preclinical Services?
A Contract Research Organization (CRO) offering zebrafish services enhances preclinical services by providing rapid, cost-effective, and high-quality data from preclinical testing. Leveraging zebrafish for preclinical trials ensures a thorough examination of the drug candidate, aligning with regulatory requirements and assisting in smooth transitions to clinical development.

3. What role do zebrafish play in Preclinical Testing for Medical Devices and Drug Development?
In preclinical testing for medical devices and drug development, zebrafish models provide insights into the biocompatibility and safety of new medical technologies and potential drug candidates. Their use helps in ensuring that the products meet the regulatory standards, thus smoothing the pathway to clinical studies and eventually to the market.

4. What is the significance of zebrafish in studying Drug Development and Preclinical Contract in Clinical Trials?
Zebrafish services offer an innovative approach for preclinical contracts in clinical trials. These animal models expedite the drug development program by enhancing the study design, ensuring regulatory submissions align with the expectations of regulatory authorities, and providing high-quality preclinical safety testing data.

5. How do Zebrafish models aid in the Drug Development Industries and Biopharmaceutical Companies?
Biopharmaceutical companies leverage zebrafish models for efficient and reliable preclinical studies, ensuring their development phase produces robust, high-quality results for a successful transition to clinical phases.

Ready to get started?

Ready to connect with us to learn more about working with our company or our technology?

Submit your inquiry below & we will get back to you soon.