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InVivo Biosystems Blog

Overcoming the Challenging Nature of Knock-Ins in Zebrafish
CRISPR Gene Editing: Tips for Injection Mix Success
Alternative Animal Models Unlock Hope in STXBP1 Epilepsy Research
Cas9 or Cas12a? Benefits of Expanding Your Gene Editing Toolbox
Preclinical Drug Discovery | InVivo Biosystems
Biological Quality Control Assay Validation Services
Zebrafish vs. Mouse Models: A New Standard in Behavioral Assays
Rapid Results: The RapidGen™ CRISPR Approach
Using Zebrafish to Combat Cognitive Decline: How a Biopharmaceutical Company Leveraged a Zebrafish Model to characterize a Compound for Neurodegenerative Disease Therapeutics
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A humanized Caenorhabditis elegans model of Hereditary Spastic Paraplegia [Where are they now: Customer Story]
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Using Zebrafish Custom Injection Mixes to Accelerate the Grant Application Process
History of CRISPR: Cas9 and Cas12
What are Knock-outs and Knock-ins?
Differences Between HDR vs NHEJ
How Do Knockins Work?
The ABCs of Genetic Research
Zebrafish 101: A White Paper
C. elegans 101: A White Paper
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Nutraceuticals & New approaches to DMD treatment
Neuroscience Models: Transgenic Mice, Zebrafish, C. Elegans – And Jellyfish?
The State of Knock-ins in Zebrafish
What’s a Knockout, Really?
Let’s Fail Faster: Why Scientific Failures Should be Accepted as Progress
So What is Humanization?
Check it before you wreck it
The Next Generation of Animal Models: Humanized Models
Hey People ….its SSSH! time – Getting Easier Integration via Transgenesis Innovation
Bottom line: Getting some SSSH! time with this split-hygR technique can calm the frustration of the aggravated C. elegans researcher.
Alzheimer’s – Have we been approaching it all wrong?
A new finding has set the Alzheimer’s research world abuzz: a 73- year old woman with extremely high risk for AD, yet who doesn’t have
Whole Gene Humanization for Personalized Medicine Applications
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for
Zebrafish Genome Editing: CRISPR vs. Tol2
One of our scientists compares two popular genome editing tools, CRISPR and Tol2 to better understand the pros and cons of each technology
A Spotlight on Recent Zebrafish Research
We’ve compiled some of the most recent informative and influential research being done using the zebrafish model
How do I get rid of this pesky protein? The Hows and Whys of Protein Degradation
Being able to understand how a protein acts in specific tissues and times can be key for the general understanding of a protein’s function.
90 Mutations with 1 Gene: Functional Analysis of Variants Using C. elegans
We created over 90 point mutations in the STXBP1 gene via CRISPR. A map of these point mutations can be seen above. Clinical variants were
11 Steps to a Successful CRISPR Knock-in
Knock-ins are hard, for a long time people even said they were impossible, but we are nearing an 80% success rate for CRISPR knock-ins in
The Challenge of Getting CRISPR-based Knock-ins to Work in Zebrafish
We take a look into why so many zebrafish groups struggle to achieve knock-in transgenesis and what makes knock-ins so difficult.
6 Things That Can Go Wrong While Making Your Zebrafish CRISPR Knock-In
CRISPR technologies enable humanized animal models to aid disease research
C. elegans as a model to evaluate the function of disease genes In 1998, the soil nematode Caenorhabditis elegans became the first multicellular organism of
Article Review: The Caenorhabditis elegans Transgenic Toolbox
We reviewed a recent article that discusses the best techniques available for C. elegans transgenics, as well as experimental concerns that should be considered.
C. elegans as Fast and Affordable System for Variant Phenotyping
Systems for Functional Studies A variety of modeling systems can be used to explore variant function. Initially, many researchers turn to a computational approach to
Worming into Relevance – Human disease models in the C. elegans nematode
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
KCNQ2 epilepsy gene
Functional analysis of variants to aid understanding of children’s epilepsy
Performing sequence analysis on a patient with a suspected genetic disease is becoming a standard of care. However, when a genetic variation is identified as
Worming into Relevance – Human disease models in the C. elegans nematode
The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and
CRISPR/Cas9 off target effects: Hyperactive cutting or media hype?
There has been a lot of media coverage in recent months surrounding CRISPR/Cas9 and the potentially life changing impact the gene-editing technology could have. More
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