In the scientific community there is an emphasis on positive results: getting published, having a drug be approved, etc. However, crucial learning happens when experiments don’t work – in fact, these “failures” may be some of the most important learning experiences. In this article we discuss the need to shift the focus from failing less, to failing faster and some of the resources available to researchers so they can expedite their own work.
In an effort to create better research models for epilepsy, we’ve been working on a grant-funded project to humanize numerous C. elegans genes. Learn more about our progress and our findings in this blog.
Humanized animal models are becoming more widely used as new gene editing techniques become available and there is a push for a more personalized approach to medicine, but what exactly is humanization? In this article we discuss the history, the types of humanized models, and how they can be applied to your research.
New ‘humanized models’ have the potential to revolutionize the study of clinical diseases, creating models with higher validity than more traditional models. This in turn has the power to expedite getting results from the bench to the bedside. In this article we will discuss the current state of animal models and the future that humanized models make possible; as an example, we will specifically focus on the models of Alzheimer’s Disease (AD).
We have found whole gene humanization can create a platform for highly translatable results in a model organism. Currently there is a big need for functional studies of Variants of Uncertain Significance (VUS).