Drug Toxicity - InVivo Biosystems

Worms on drugs: How well can C. elegans predict drug toxicity in mammals?

Aging & Healthspan, Drug Toxicity, View from the Bench / By Adam Saunders / September 1, 2020 November 9, 2020

One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.

The Evolution of Drug Resistance; an Issue of “When, not if”

Disease Modeling, Drug Toxicity, View from the Bench / By Janis Weeks, Ph.D. / September 25, 2019 November 10, 2020

Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal health. Resistance is manifested by a decreased ability, or complete failure, of previously-effective drugs to successfully prevent or clear infections. Well-known human examples include methicillin-resistant Staphylococcus aureas (MRSA); multi-drug resistant …

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wMicroTracker Applications: Drug Screening

Drug Discovery, Drug Toxicity, View from the Bench / By Yoanne Clovis, Ph.D. / October 9, 2018 November 10, 2020

The wMicroTracker is a great product to add to your drug screening toolkit. Check out the application sheet below to see how easy it is to use and how it can positively impact your research.