In the age of industries continuously creating and remodeling chemicals, having a reliable way to test their toxicity is vital. At the same time, across all areas of research, there is the desire to shift away from traditional animal models. In this article we outline the New Approach Methods (NAMs) and some of the steps being taken to implement them.
One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.
Drug resistance in many pathogens — viruses, bacteria, protozoa, parasitic worms and more — presents a growing and potentially catastrophic challenge to human and animal health. Resistance is manifested by a decreased ability, or complete failure, of previously-effective drugs to successfully prevent or clear infections. Well-known human examples include methicillin-resistant Staphylococcus aureas (MRSA); multi-drug resistant …