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View from the Bench

Microfluidic EPG Recordings From Diverse Nematode Species

The InVivo Biosystem ScreenChip platform was developed for C. elegans, which is a free-living (non-parasitic) species that feeds on bacteria and has both hermaphroditic and male sexes. However, C. elegans represents only one of the estimated 1 million members of the highly diverse phylum Nematoda, of which only ~25,000 species have been described. In addition to free-living species, other nematodes parasitize humans, animals or plants, with significant medical, veterinary and economic consequences. To demonstrate the utility of microfluidic EPG recordings from species beyond C. elegans, we adapted the platform to record from human and animal parasites, male and female members of a dioecious species, and a carnivorous nematode.

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OP50 Vs. HB101: Which Food Should I Choose?

Nematode worms such as Caenorhabditis elegans feed on bacteria as a food source. In the wild, C. elegans obtain various bacteria from rotting plants, fruit, and vegetation, but under laboratory conditions, C. elegans is normally cultured on agar plates with a standardized bacterial lawn.  There are many bacterial diets used for culturing C. elegans. The …

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C. elegans CV

C. elegans CV

When you have to apply for a new job, you are asked to provide a resume, CV, and a cover letter. So why then aren’t you asking the same of the model organisms you are using? We put together a fun, yet very informative, C. elegans CV for you to learn more about the small worm and why it makes an ideal model for studying human diseases.

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worms on drugs featured image

Worms on drugs: How well can C. elegans predict drug toxicity in mammals?

One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.

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