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HomeInVivo Biosystems BlogAging & HealthspanModeling Gut Microbiome Effects in Alternative Animal Models – Finding the Happy Biota for a Long and Healthy Life

Modeling Gut Microbiome Effects in Alternative Animal Models – Finding the Happy Biota for a Long and Healthy Life

What is the microbiome? How does it help or hinder health? And, what does recent research indicate? 

 

We’ve all had that regret: “oh, I should not have eaten that.” But recently, research has shown that your discomfort can be an indicator of your gut microbiome’s homeostasis. The human microbiome refers to the combination of microbes and their genes (bacteria, fungi, protozoa and viruses) that exist inside and outside of the human body [1]. Consisting of 10-100 trillion cells, the human microbiome which is essential for digestion has many health benefits ranging from regulating our immune system to producing the vitamins which are needed for blood coagulation. While microbes colonize most surfaces on our bodies: skin, nasopharynx, oral cavity, urogenital tract, and gastrointestinal tract, the vast majority of humans’ interaction with our microbes occurs in the gastrointestinal gut. 

The human intestine harbors at least 100x more bacteria than the entirety of our embryo-derived cells. As a result, these bacteria (or to be more exact "microbiome") can have a profound impact on our health. This number of microbes is startling, however, what determines a person’s place on the disease-to-health spectrum is not the number of bacteria, but how diverse these bacteria are. The types of bacteria found in our gut are stratified between the intestine and colon [1]. In the intestine, the microbes that reside there are optimized to digest easy to metabolize compounds (simple sugars, fats, amino acids, and other molecules); while in the colon, the resident microbes specialize in fermenting digestion of complex carbohydrates [2].

Figure 1 - Spatial distribution and concentrations of bacteria along the gastrointestinal tract of humans [3]

Figure 1. Spatial distribution and concentrations of bacteria along the gastrointestinal tract of humans [3]

It’s true that the microbiome includes both symbiotic and pathogenic microbes —  in a healthy person, these ‘bugs’ coexist without causing harm. However, when there is an abnormality in this microbial ecosystem, known as dysbiosis, a person can be at higher risk of developing diseases such as nonalcoholic fatty liver disease, cardiovascular disease, obesity, diabetes, depression, Parkinson’s disease, autism, and various gastrointestinal cancers [4]. Because of this, there has been a recent increased interest in how microbe populations influence each other (microbe-microbe interactions). And also how microbes, especially pathogenic microbes, sustain themselves inside people (host-microbe interactions).

Figure __. Social interactions among microbes. Microbes frequently interact with clonemates or other microbes of the same or different species (represented by microbes of different colors and shapes, respectively) [5].

Figure 2. Social interactions among microbes. Microbes frequently interact with clonemates or other microbes of the same or different species (represented by microbes of different colors and shapes, respectively) [5].

One of the key areas microbiome researchers are exploring is gut plasticity, asking whether researchers can use their newfound knowledge of the gut microbiome to design interventions that not only treat disease, but improve healthspan [1]. So far it looks promising: the gut microbiome can trigger systemic inflammation, which is an aspect of “inflammageing” (chronic inflammation that accumulates with age), and dysbiosis has been implicated in several age-associated neurodegenerative diseases [6]. Better understanding of how the microbiome changes with age, what the microbes’ role is in the bidirectional communication between the gut and brain (the gut-brain axis), and how these systems interact with our immune defenses, could enable targeted interventions that improve our lifespans and healthspans.

microbiome healthspan circle

Figure 3. The gut microbiome, immune system, and brain all cross-communicate and can be modulated by interventions to improve healthspan and lifespan. Some interventions may more directly impact one system, some may impact indirectly, such as the direct impact of diet and fecal transplant, and the indirect impact of exercise on the gut microbiome. Nonetheless, the gut microbiome, the brain, and the immune system are all connected to one another, and along with age, change in one system can subsequently impact the other systems, ultimately impacting healthspan and lifespan as well. Moreover, the impact of individuals and combinations of interventions on the key players of healthspan and lifespan are still being explored [6].

To find out more details and learn more on how healthy microbiomes can be studied in animal models, please download our white paper at the link below. 

In this white paper you will learn:

  • The external effects (diet, environment, birth) on microbiome
  • Microbiome products and therapies
  • The functional foods and medicinal foods markets & the companies making them
  • Regulatory concerns
  • Traditional and alternative models to research microbiome
  • More...

References

  1. Ursell LK, Metcalf JL, Parfrey LW, Knight R. Defining the Human Microbiome. Nutr Rev. 2012;70: S38.
  2. Donaldson GP, Lee SM, Mazmanian SK. Gut biogeography of the bacterial microbiota. Nat Rev Microbiol. 2016;14: 20–32.
  3. Rivière A, Selak M, Lantin D, De Vuyst L. Figure 1: Spatial distribution and concentrations of bacteria along the. 28 Jun 2016 [cited 27 Oct 2021]. Available: https://www.researchgate.net/figure/Spatial-distribution-and-concentrations-of-bacteria-along-the-gastrointestinal-tract-of_fig4_304577663
  4. Grover K, Gregory S, Gibbs JF, Emenaker NJ. A discussion of the gut microbiome’s development, determinants, and dysbiosis in cancers of the esophagus and stomach. J Gastrointest Oncol. 2021;12: S290–S300.
  5. Figueiredo ART, Kramer J. Cooperation and Conflict Within the Microbiota and Their Effects On Animal Hosts. Front Ecol Evol. 2020;0. doi:10.3389/fevo.2020.00132
  6. Narasimhan H, Ren CC, Deshpande S, Sylvia KE. Young at Gut—Turning Back the Clock with the Gut Microbiome. Microorganisms. 2021;9. doi:10.3390/microorganisms9030555

About the Author: Alexandra Narin

Alexandra Narin

Alexandra is a Content Marketing Specialist and Grant Writer for InVivo Biosystems. She graduated from the University of St Andrews in 2020 where she earned a Joint MA Honours Degree in English & Psychology/Neuroscience with BPS [British Psychology Society] Accreditation. She has worked as a research assistant, examining the LEC's (lateral entorhinal cortex) involvement in spatial memory and integrating long term multimodal item-context associations, and completed her dissertation on how the number and kinds of sensory cues affect memory persistence across timescales. Her hobbies include running, boxing, and reading.

About the Author: Hannah Huston

DSC_0132

Hannah is the Marketing Manager at InVivo Biosystems. She received her Bachelor of Science in Science & Management specializing in Biotechnology from Scripps College in 2017. She has been with InVivo Biosystems since June of 2018. Outside of work Hannah coaches youth soccer and enjoys being active and outside with her dog, Siri.

About the Author: Chris Hopkins, Ph.D.

Chris-

Dr. Chris Hopkins is the Chief Scientific Officer at InVivo Biosystems. He pioneered the commercialization of C. elegans transgenics. As a scientist turned entrepreneur, he now pioneers the application of humanized animal models for clinical variant prototyping.

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