“When people talk about ‘model organisms,’ many people think that the animal has to ‘model’ the human disease condition to have any impact. We argue that this is not the case. Simply studying what the homologous gene does in the context of the model organism can provide important insights into disease pathology. Rare genetic variants can be modeled in a number of different model organisms, informing causality between a particular variant and a pathogenic phenotype and offering clinicians and their patients hope for a diagnosis, insight into the mechanisms and pathways involved in a rare disease, and ways it might be treated.” Neff, E.P. Model matchmaking. Lab Anim 50, 39–42 (2021).
Using CRISPR and other genome editing methods, InVivo Biosystems can humanize or genetically engineer Zebrafish and C. elegans into powerful animal models for better understanding genetic mutations and disease biology discovery.
There are two types of humanizing changes can be made:
Humanization with Point Mutation
Humanization with Whole Gene
We work with scientists seeking new or alternative ways to approach their research.
InVivo Biosystems is ready to help you with your COVID-19 research! We offer our genetic expertise in the engineering of humanizations, fluorescence markers, luciferase, activity reporters, and conditional expression to help you interrogate drug and vaccine activity, binding interactions, mechanism of action, and more.