Question: What might you get if you cross the feeding organ of a roundworm with a genome wide association study? Answer: A cornucopia of novel
There are approximately 7,000 rare diseases in humans, ~80% of which are monogenic. A rare disease is defined as affecting less than one in 1,500 people. Combined, these rare diseases affect nearly 1 in 10 Americans (25 to 30 million people), and treatments only exist for around 5% of these diseases. Thanks to the advent of whole genome sequencing, the gene(s) responsible for many rare diseases are known, opening the door for more comprehensive studies.
Recent improvements in our knowledge of the natural environment of C. elegans should make us cautious about the conclusions we draw from observations of worm behavior on agar plates. Do microfluidic devices offer a more naturalistic alternative?
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An expert in CRISPR genome editing, InVivo Biosystems creates custom genome-edited C. elegans and zebrafish models to enable aging, developmental, and disease studies. Our unique in vivo platforms and technologies bridge the gap between cells and mice.