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What Is Lifespan And Healthspan – And How Are They Connected?

Summary

Humans are living longer than any other time in history, but what is the quality of life during these years? This article will discuss lifespan and health: what are they, how are they different, and how are they connected?

The last century has seen a rapid increase in life expectancy: in the USA life expectancy has nearly doubled from 1900 to 2010 (47.3 to 78.7 years) (Crimmins, 2015). And this is not just limited to the US – worldwide there was a 6 year increase in life expectancy between the years 2000 and 2019 (66.8 to 73.4 years) (GHE: Life Expectancy and Healthy Life Expectancy, n.d.) While one might think living longer is better, a long life is not necessarily synonymous to living a healthy life. Lifespan refers to the total number of years alive, whereas healthspan is how many of those years are lived free from serious disease (Harvey A. Friedman Center for Aging, 2017)

While the USA’s life expectancy is tracked by the National Center for Health Statistics and the Center for Disease Control and Prevention (CDC), which collects and reports on the data yearly, no such measure exists for healthspan (Arias et al., 2021) This is because aging is not recognized as a ‘disease’ by the US federal government; in fact, no country in the world has classified biological aging to be a disease (Bulterijs et al., 2015)

To meet this gap in data, the World Health Organization (WHO) began collecting Healthy Life Expectancy data, nicknamed HALE (Harvey A. Friedman Center for Aging, 2017). HALE is calculated utilizing the Sullivan Method, which calculates the number of years-lived for specific age intervals, based on the probability of death at each stage. Then, the number of years lost due to disability (YLD) are estimated – with adjusted weight for severity, The sum of years lived without these ‘years lost to disability’ is considered the health-adjusted years lived at each age interval [Figure 1]. Ultimately, HALE is the cumulative number of health-adjusted years, divided by the total years lived by each age interval (WHO, 2014).

disability adjusted year

Figure 1. What is a Disability Adjusted Life Year (DALY)? It is a measure of the overall burden of disease – it adds the years of life lost with the years lived with disability or in ill health together. DALYs allow us to make comparisons between countries(Middlesex University Public Health Society, 2018)

DALY_Village

Figure 2. How is Disability Adjusted Life Year (DALY) Calculated? (PSI, 2021).

Like lifespan, healthspan has increased from 2000 to 2019, however, they are not increasing at the same rate: lifespan rose 6.6 years while HALE only increased 5.4 years)(GHE: Life Expectancy and Healthy Life Expectancy, n.d.-b) [Figure 2].

lifespan:healthspanadjusted

Figure 3. Lifespan is the total number of years lived by an individual. Healthspan is the number of disease-free years lived. Life expectancy and health-adjusted life expectancy are population-level measures of lifespan and healthspan, respectively. A gap of 9-year is deduced from comparing 2020 data for median probabilistic projection of life expectancy and health-adjusted life expectancy. Figure adapted from Garmany et al., 2021.

    This means, on average, we are unhealthy for 13% of our lives

So where do we go from here? 

The good news is that, being aware of this healthspan-lifespan gap means we can work on finding ways to treat it: the “geroscience hypothesis” suggests that aging is the number one risk for all chronic diseases, and thus, when trying to improve healthspan it would be more advantageous to treat the underlying factors of aging rather than treating each chronic condition at a time (Tournas & Marchant, 2019).

Already there is a lot of research being conducted utilizing one of the premiere models for lifespan studies: C. elegans. This being said, healthspan will be a field to watch in the coming years – check out recent articles using C. elegans below. Or read part two of our lifespan/healthspan blog series for a comparison of the models being used in this research. 

References

  1. Le et al. (2020) has developed the Health and Lifespan Testing Hub (HeALTH),which is an automated, microfluidic-based system that enables the long-term monitoring of behaviour and healthspan in C. elegans.
  2. Bareja, Lee & White (2019) published a detailed review on the key signaling pathways associated with aging. 
  3. Bansal et al. (2015) examined multiple pathways that modulate lifespan to investigate the relationship between lifespan extension and health. They analyzed wild-type and four long-lived mutants and showed that lifespan and healthspan can be separated and all of the long-lived mutants extend the period of frailty as a consequence.
  4. Hansen & Kennedy (2016) discussed the pathways associated in lifespan extension and asked whether they are also improving healthspan.

 

Glossary:

  • Lifespan: the length of time a person lives
  • Healthspan: the length of time a person lives free of major/chronic disease
  • HALE: Healthy Life Expectancy
  • YLD: Years of healthy life lost due to disability
  • DALY: Disability Adjusted Life Year
  • Geroscience Hypothesis: aging underlies most, if not all, chronic diseases. By treating aging physiology chronic diseases will be avoided or mitigated (expand healthspan).

References

  1. Arias, E., Tejada-Vera, B., & Ahmad, F. (2021). Provisional life expectancy estimates for January through June, 2020. https://doi.org/10.15620/cdc:100392
  2. Bulterijs, S., Hull, R. S., Björk, V. C. E., & Roy, A. G. (2015). It is time to classify biological aging as a disease. Frontiers in Genetics, 6. https://doi.org/10.3389/fgene.2015.00205
  3. Crimmins, E. M. (2015). Lifespan and Healthspan: Past, Present, and Promise. The Gerontologist, 55(6), 901-911.
  4. Garmany, A., Yamada, S., & Terzic, A. (2021). Longevity leap: mind the healthspan gap. Npj Regenerative Medicine, 6(1), 1-7.
  5. GHE: Life expectancy and healthy life expectancy. (n.d.). Retrieved October 12, 2021, from https://www.who.int/data/gho/data/themes/mortality-and-global-health-estimates/ghe-life-expectancy-and-healthy-life-expectancy
  6. Harvey A. Friedman Center for Aging. (2017). Healthspan is more important than lifespan, so why don’t more people know about it? https://publichealth.wustl.edu/heatlhspan-is-more-important-than-lifespan-so-why-dont-more-people-know-about-it/
  7. Tournas, L., & Marchant, G. E. (2019). The Fountain of Youth Revisited: Regulatory Challenges and Pathways for Healthspan Promoting Interventions. Food and Drug Law Journal, 74(1), 18-45. https://www.jstor.org/stable/2682697
  8. WHO (2014). WHO methods for life expectancy and healthy life expectancy. Global Health Estimates Technical Paper. https://www.who.int/data/gho/indicator-metadata-registry/imr-details/66

About the Author: Alexandra Narin

Alexandra Narin

Alexandra is a Content Marketing Specialist and Grant Writer for InVivo Biosystems. She graduated from the University of St Andrews in 2020 where she earned a Joint MA Honours Degree in English & Psychology/Neuroscience with BPS [British Psychology Society] Accreditation. She has worked as a research assistant, examining the LEC’s (lateral entorhinal cortex) involvement in spatial memory and integrating long term multimodal item-context associations, and completed her dissertation on how the number and kinds of sensory cues affect memory persistence across timescales. Her hobbies include running, boxing, and reading.

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