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Behavior & Morphology Analysis of C. elegans

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Behavior & Morphology Analysis​

Our C. elegans behavior and morphology analysis platform measures 26 individual characteristics of the morphology and movement patterns of individual animals. This is a deep phenotypic characterization that is well suited to later analysis using sophisticated machine learning techniques.

Service Overview

Our platform offers:

  • Comprehensive analysis of C. elegans morphology, including length, width, area, and wavelength.
  • Detailed movement pattern study, focusing on forward and reversal speeds.
  • Expert interpretation, ideal for researchers targeting subtle genetic or chemical-induced changes.
 
 

Select & Compare: Choose age-matched C. elegans from at least two distinct groups for a holistic comparison. We analyze and use high-throughput sequencing techniques to compare the two groups and identify differences between them at the genetic and genomic levels. Results are evaluated to gain insight into the impact of environment factors on C. elegans.

Record & Analyze: Capture crawling or swimming behaviors. Analyze the results to determine changes in gene expression and localization. Examine the effects of environmental factors on C. elegans.

Morphology (length, width, area, wavelength) Morphology can also be used to measure the rate of growth and movement. Additionally, it can be used to measure the overall shape of a cell, such as whether it is circular or elongated. Morphological changes can also provide insight into cellular function.

Software-Driven Insights: Benefit from our specialized software that identifies and quantifies intricate behaviors. Our software can also help you identify potential therapeutic targets, understand disease mechanisms, and discover novel therapeutics.

  • Data Only: A spreadsheet report including the quantification of the 26 analyzed features

  • Data interpretation: A report analyzing differences between the two groups with statistical software and PCA analysis
  •  Teasing out subtle phenotypes in the behavior and morphology of genetic mutants and/or chemically treated animals.
bar chart of Quantified differences in area and forward speed for 7 different genotypes of C. elegans modeling point mutations in STXBP1, a gene important for epilepsy

Quantified differences in area and forward speed for 7 different genotypes of C. elegans modeling point mutations in STXBP1, a gene important for epilepsy.

Service Offerings

Data Only

Data Interpretation

Data Customization

Timeline

2-3 months

2-3 months

2-3 months

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