Why Use Zebrafish?
Studies have confirmed that mammalian and zebrafish toxicity profiles are strikingly similar. In addition, zebrafish organs are similar to human in cellular composition, function, signaling, and response to injury as well as the cellular processes that mediate organ-specific diseases.
Many genes are highly conserved between humans and zebrafish, making them a useful system to study the basic mechanisms of organ-specific diseases, such as heart, liver or neurological disorders.
Zebrafish develop rapidly; all of their major organ systems become fully formed during the early larval stages, making it a recognized standard model to assess organ toxicity.
Even at an early stage, zebrafish show concordance at a metabolic pathway level, confirming its utility as a model to screen the toxic potential of compounds on major organs*.
Blog: Zebrafish Acute Toxicity Study Demonstrates Concordance with Rat Fetal Embryotoxicity.
Our toxicity testing is performed using automation and customized software for data collection and analysis. Our main testing services include:
Determine whether a compound or formulation induces liver damage. Measurements using early life-stage zebrafish include gross tissue health, necrosis, liver function and cell death.
Assess whether a compound or formulation induces nervous system damage. Early life-stage zebrafish will be used to measure neural gene expression via qPCR.
Assess whether a compound or formulation induces heart damage in zebrafish. Early life-stage zebrafish will be used to assess cardiac function.
Other Testing Services
Embryo Acute Toxicity Test
Determine the acute or lethal toxicity of chemicals on embryonic stages of fish (Danio rerio).
Early-life Stage Toxicity Test
Determine the lethal and sub-lethal effects of chemicals on the early life stages of the fish tested.
Zebrafish behavioral phenotyping
Assess photomotor response, measure anxiety behaviors, or understand learning and memory mechanism.
Understand Your Goal
We will set up a 30-minute call with you to understand your needs. During this call, we will define the scope of your project, answer your practical questions and help you assess whether our service is a good fit for you.
Create A Personalized Catalog
After we decide on the scope of the project, we will create a proposal that includes cost and time estimate for each experiment proposed. You will be able to personalize your project plan.
Finalize Your Project Design
We will send you a final statement of work and payment schedule. Once we receive your first PO, we will start the experiments and give you a defined timeline for your project.
Maintain Clarity And Transparency
We will keep you updated every two weeks on the status of your project. At the end of your project, we provide you with a report that includes comprehensive findings and key takeaways.
READY TO GET STARTED?
Ready to connect with us to learn more about working with us on toxicity testing?