Preselected Neurodegenerative Disease-Relevant Models
The ability to quickly install variant alleles in C. elegans and zebrafish, and quantitatively measure the variant phenotypes provides researchers a path to rapidly address the consequence of gene variation for answering questions of disease biology.
We have preselected disease-relevant models and validated their genetic identity with PCR and sequencing. These humanized model systems can serve as another efficient tool set to study human diseases.
We can create other neurodegenerative disease-relevant models using zebrafish and C. elegans, including Frontotemporal Degeneration and Huntington's diseases.