Preselected Neurodegenerative Disease-Relevant Models
The ability to quickly install variant alleles in C. elegans and zebrafish, and quantitatively measure the variant phenotypes provides researchers a path to rapidly address the consequence of gene variation for answering questions of neurodegenerative disease biology.
The image below illustrates C. elegans as a transgenic model for studying gene variations associated with Alzheimer’s Disease (AD) and Frontotemporal Dementia (FD).
C. elegans as a transgenic model for studying Alzheimer’s Disease (AD) and Frontotemporal Dementia (FD).
Red text: AD human genes expressed with worm gene homologue (in parentheses).
Purple text: FD human gene express with worm gene homologue (in parentheses).
Phenotypes observed are written close to the arrow.
We have preselected disease-relevant models and validated their genetic identity with PCR and sequencing. These humanized model systems can serve as another efficient tool set to study human diseases.
We can create other neurodegenerative disease-relevant models using zebrafish and C. elegans, including Frontotemporal Degeneration and Huntington's diseases.