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An Abnormal Absence of Antibodies: Filling the Gaps with Gene Editing Tools in Zebrafish

The zebrafish is an increasingly popular laboratory organism with many experimental advantages. The animal model has been used by biologists to discover the detailed processes that underlie vertebrate development and disease, and study vertebrate haematopoiesis and immune cell interactions1. The zebrafish embryo is also a popular vertebrate model for neurobiology2. Zebrafish research, however, is limited …

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Reproducibility of behavioral data from C. elegans transgenics with the ScreenChip system

As a service provider, we often use the same technologies/products that we provide to our customers to run experiments in our own lab. Recently, we put our own ScreenChip System to the test. As part of a project for one of our customers, we used CRISPR-Cas9 to generate a complete gene knockout in C. elegans and assessed its effect on pharyngeal pumping. Pharyngeal pumping is …

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Genome wide associations and the nematode pharynx: ever the twain shall meet

Question: What might you get if you cross the feeding organ of a roundworm with a genome wide association study? Answer: A cornucopia of novel genes for synaptic transmission, neuromodulation, energy regulation, peptidergic signaling, learning and memory, and more. This riddle, and its answer, are prompted by the convergence of two exciting trends in research …

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