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Alexandra Narin

What the Undiagnosed Diseases Network is, How it Works, and How InVivo Biosystems is Doing its Part

The Undiagnosed Diseases Network UND is a nationwide network that is working to understand and diagnose rare and undiagnosed human diseases. The UND coordinates between research and clinical experts, using the latest genetic and genomic technologies to create a more personalized medicine model.

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From Unknown to Known: How the Zebrafish Model is Playing a Vital Role in the Undiagnosed Diseases Network

The Undiagnosed Diseases Network brings together experts across the USA, combining clinical care and research to find diagnoses for undiagnosed patients. Zebrafish are extremely valuable disease models in this research, as they reduce the cost and speed up the process of identifying therapeutic targets. In this blog we highlight one rare disease whose mechanism was successfully identified using zebrafish.

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Let’s Fail Faster: Why Scientific Failures Should be Accepted as Progress

In the scientific community there is an emphasis on positive results: getting published, having a drug be approved, etc. However, crucial learning happens when experiments don’t work – in fact, these “failures” may be some of the most important learning experiences. In this article we discuss the need to shift the focus from failing less, to failing faster and some of the resources available to researchers so they can expedite their own work.

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The 3Rs of Animal Research: Are the guidelines working? How can we do better?

A common saying in science is that, “good science and good animal welfare go hand in hand.” In this article we provide an overview of the 3Rs (Replacement, Reduction and Refinement: guiding principles for the humane use of animals in research), look specifically at the UK’s well-documented implementation of them, and discuss how new techniques and technologies can continue to improve animal welfare.

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So What is Humanization?

Humanized animal models are becoming more widely used as new gene editing techniques become available and there is a push for a more personalized approach to medicine, but what exactly is humanization? In this article we discuss the history, the types of humanized models, and how they can be applied to your research.

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The Path to Affordable Therapeutics in Rare Disease – Tackling Congenital Disorder of Glycosylation in the PMM2 gene.

Rare diseases are just that: rare. However, when combined rare diseases affect 3.5% – 5.9% of the worldwide population, and present a growing healthcare issue. In this article we talk with Dr Sangetha lyer about her work at the biotech Perlara and highlight their recent successes in a drug repurposing campaign for PMM2-CDG.

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The Next Generation of Animal Models: Humanized Models

New ‘humanized models’ have the potential to revolutionize the study of clinical diseases, creating models with higher validity than more traditional models. This in turn has the power to expedite getting results from the bench to the bedside. In this article we will discuss the current state of animal models and the future that humanized models make possible; as an example, we will specifically focus on the models of Alzheimer’s Disease (AD).

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