Cancer
Powered by the ZTX® Platform in Partnership with BioReperia
Cancer Modeling via Zebrafish Tumor Xenograft for Drug Discovery and Development
IVB’s zebrafish-based tumor-xenograft platform enables rapid, translational efficacy testing of cancer therapies so you can make decisions faster and with greater confidence.
Why Use Zebrafish for Cancer Research??
Zebrafish provide a rapid, human-relevant in vivo system that accelerates the evaluation of tumor growth, metastasis and therapeutic response.
Rapid Modeling
Tumors engraft and expand within days, enabling fast readouts for growth, invasion and treatment response.
Human Relevance
Zebrafish embryos can host human tumor cells and immune cells, supporting functional oncology and immune-oncology testing.
Scalable Screening
High-throughput imaging and compound delivery make it possible to evaluate many candidates in parallel with strong translational value.
Clear Visual Readouts
Transparent embryos allow direct visualization of tumor progression, vascularization and metastatic spread in live animals.
Cost Efficiency
Lower per-study cost compared to rodent models enables earlier in vivo validation and better decision making.
One Oncology Platform, Multiple Purposes
Full-Service Oncology Modeling Capabilities
The ZTX® platform delivers flexible utility across oncology discovery and development. It enables rapid evaluation of immune-oncology therapeutics, supports CDX and PDX tumor modeling, and reliably hosts human immune cells for functional assays. The platform accommodates a wide range of compound modalities, including small molecules, antibodies, ADCs and nanoparticles, giving teams a single in vivo system for diverse therapeutic strategies.
Model Generation
Implantation of CDX, PDX or primary human tumor tissue into zebrafish embryos, enabling rapid microtumor formation and accelerated model development.
Behavioral & Tumor Tracking:
Rapid imaging of tumor growth, vascularization and metastasis in live zebrafish.
Immune-Oncology Evaluation
Human immune cells are readily hosted in zebrafish embryos without modification, supporting functional testing of T-cell therapies, checkpoint inhibitors and autologous approaches.
Compound Screening & Profiling
Efficacy testing of small molecules, peptides, biologics, antibodies, ADCs and nanoparticles for tumor regression and invasion suppression.
In Vivo Oncology Capabilities
Advanced Capabilities That Support Your Oncology Discovery
Live Tumour Imaging & Metastasis Tracking
Our zebrafish platform enables real-time visualization of tumor growth, vascularization and metastatic spread within days, giving you fast, actionable insights.
Immune-Cell Engraftment & IO Testing
We integrate human immune cells into zebrafish tumor models to assess checkpoint inhibitors, T-cell therapy and combination strategies with human-relevant interactions.
High-Throughput Compound Efficacy Testing
Test small molecules, biologics, ADCs and nanoparticles in a rapid, scalable in-vivo system, accelerating screening of lead candidates in days instead of months.
Mechanistic Profiling & Biomarker Read-Outs
Post-treatment analyses include pathway profiling, RNA sequencing, immune infiltration assays and vascular invasion quantification to deepen mechanistic understanding.
How IVB’s Zebrafish Tumor Xenograft Workflow Works
1: Human tumor cells (cell line, PDX or patient sample) are implanted into zebrafish embryos.
2: Human immune cells are engrafted (for immune-oncology studies) and compound treatment is applied.
3: Tumor growth, vascularization and metastasis are monitored over days using live imaging and automated tracking.
4: Data outputs are generated: tumor regression metrics, metastasis inhibition, immune-cell activity and pathway responses. Results are delivered in a format aligned to your decision-making needs.
The Zebrafish Oncology Solution
The ZTX® platform is a tool for both accelerated drug discovery and personalized medicine.
The zebrafish model is used to produce oncologic xenografts which are then used in PDX, CDX, and primary patient tumors to discover and validate oncologic treatment outcomes.
Zebrafish as an Oncology Model
The fast development of the zebrafish embryo enables rapid vascularization of a developed microtumor. The solid microtumor becomes vascularized and a tumor microenvironment can be reconstituted within 3 days, both of which allow metastasis invasion.
Validation of Therapeutic Outcome at Record Speed
The ZTX® platform is a reliable companion diagnostic tool to use in CDX and PDX studies. The platform has a 79% treatment correlation to traditional PDX therapeutic outcome, while cutting up to 98% of the average validation study time.
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