Multiplexed Intermixed CRISPR Droplets:
MIC-Drop™
Welcome to the Future of Genetics
Introducing MIC-Drop™, the groundbreaking multiplex CRISPR technology by InVivo Biosystems that is set to transform the landscape of genetic research. With the power to edit multiple genes simultaneously, MIC-Drop™ offers unparalleled efficiency, precision, and scalability. Elevate your genetic engineering, accelerate preclinical drug development, and unlock new possibilities in genetics with MIC-Drop™ – where innovation meets excellence.
What is MIC-Drop™?
MIC-Drop™ is our state-of-the-art multiplexed gene editing tool, leveraging the power of CRISPR technology. Unlike traditional CRISPR-Cas9 methods that target single genes, MIC-Drop™ enables precise, concurrent modifications of multiple genetic targets. This means faster results, more comprehensive genetic engineering, and unprecedented insights into genetic functions and phenotypic correlates.
Join the Genetic Revolution Today
Applications to Drug Discovery & Development
- Confirmation of phenotypic outputs for drug development and disease modeling.
- Gene and target validation for preclinical development at unbeatable speed.
- Minimizes resource constraints by reducing late-stage failures and refining therapeutic options earlier in preclinical development.
The Multiplexed Intermixed CRISPR Droplet (MIC-Drop™) Approach
The MIC-Drop™ approach scales CRISPR/Cas9 gene editing by using single-guide RNAs for biallelic conversion within the generation in which the gene edit is performed (F0 gene disruption). This approach vastly scales up the number of gene targets in a single injection session with non-linear scaling of labor.
Innovative Advantages:
Other Offerings
Hepatotoxicity Testing
Determine whether a compound or formulation induces liver damage. Measurements using early life-stage zebrafish include gross tissue health, necrosis, liver function and cell death.
Assess whether a compound or formulation induces nervous system damage. Early life-stage zebrafish will be used to measure neural gene expression via qPCR.
Cardiotoxicity Testing
Assess whether a compound or formulation induces heart damage in zebrafish. Early life-stage zebrafish will be used to assess cardiac function.
Our Process
Introduction
Understand Your Goal
We will set up a 30-minute call with you to understand your needs. During this call, we will define the scope of your project, answer your practical questions and help you assess whether our service is a good fit for you.
Design
Create A Custom Catalog
After we decide on the scope of the project, we will create a proposal that includes cost and time estimate for each experiment proposed. You will be able to personalize your project plan.
Logistics
Finalize Project Design
We will send you a final statement of work and payment schedule. Once we receive your first PO, we will start the experiments and give you a defined timeline for your project.
Report Out
Maintain Clarity And Transparency
We will keep you updated every two weeks on the status of your project. At the end of your project, we provide you with a report that includes comprehensive findings and key takeaways.
References
Parvez, S., Brandt, Z.J. & Peterson, R.T. Large-scale F0 CRISPR screens in vivo using MIC-Drop. Nat Protoc 18, 1841–1865 (2023). https://doi.org/10.1038/s41596-023-00821-y