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Worms on drugs: How well can C. elegans predict drug toxicity in mammals?

One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.

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Zebrafish Acute Toxicity Study Demonstrates Concordance with Rat Fetal Embryotoxicity

Summary: As the zebrafish is increasingly adopted to test drug toxicity, it is critical to systematically assess the parallels between zebrafish, humans and other model systems. In this article, we highlight a recent paper that compares toxicity results obtained in zebrafish and rats. The paper concludes that zebrafish are “valuable for predicting mammalian toxic exposure …

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Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead

“Lead (Pb) is an environmental neurotoxicant, and has been implicated in several neurological disorders of dopaminergic dysfunction; however, the molecular mechanism of its toxicity has yet to be fully understood.” – Akinyemi et al. (2019) Overview Toxicology is the scientific study of the adverse effects of chemical substances or other damaging stimuli (e.g., radiation) on …

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C. elegans showing its weight in neuro-toxicology research

Researching chemicals that may cause damage to the nervous system is very challenging—of the 1,000 known toxic chemicals, only a dozen have been found to be toxic, but many unknowns exist. While mammal models remain the primary selection of research labs looking at the effects of metals and certain organic molecules on the brain—especially the …

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