Unlock the secrets of aging with InVivo Biosystems’ phenotypic screening services. Our extensive phenotypic assays includes precise assessments of lifespan, healthspan, and age-related morphological and behavioral shifts, designed to expedite research about aging. Utilizing advanced pathway analysis and swift compound testing, we deliver unmatched insights into longevity mechanisms in a mere three months.
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Aging is a complex biological process characterized by degenerative changes that progressively diminish function, leading to disease, and ultimately, death. Since it has long been a concern, the research of aging involved in gene expression and multiple pathways has been widely studied and reported. Due to the experimental challenges of studying aging in humans or other vertebrates are substantial, the easy-culturing nematode C. elegans is an excellent model system for studies of aging based on the identification of mutations, drugs, and environmental factors that extend the adult lifespan significantly. We offer a variety phenotypic measurements of age-associated changes that serve as biomarkers indicative of the physiological status of aging to provide information for aging research.
The nematode C. elegans is a powerful experimental organism for the implementation of a vast array of technologies and applied in much biological research. Unlike other single-celled organisms, such as bacteria and yeast, the millimeter-long body of C. elegans contains muscles, nerves, sexual organs, and guts, and has brought a wealth of information at the cellular level. It reacts to different environments and exhibits different responses.
InVivo Biosystems offers a series of thoughtful age-related phenotypic screening services, including lifespan and healthspan testing, age-related morphological detection, age-related behavioral detection, reproductive capacity analysis.
Effects of Drugs on Aging
Predict the acute and long term effects of your compound on the ageing organism before clinical trial. Our phenotypic screening methods are integral to this predictive analysis.
We provide the measurements of behavior and systemic changes that occur during the agin process in a live animal model.
Effects of Genetic Variants on Aging
Rapidly uncover the effects of your genetic modifications on healthspan and life expectancy using a simple animal model. Our phenotypic screening services ensure precise analysis of behavioral and systemic changes that occur during the aging in a controlled genetic context.
We provide analysis of behavioral and systemic changes that occur during the aging in a controlled genetic context.
Effects of Drugs on Neuromuscular Activity
Predict the acute and long term effects of your compound on neuromuscular activity. Phenotypic screening techniques help in providing accurate measurements of the neuromuscular changes that occur as a result of exposure to your compound.
We provide measurements of the neuromuscular changes that occur as a result of exposure to your compound.
Effects of Genetic Variants on Neuromuscular Activity
Predict the effects of the genetic changes of your choice on neuromuscular activity. Through our specialized phenotypic screening services, we provide assessment of the neuromuscular function under the genetic control of your choice.
We provide assessment of the neuromuscular function under the genetic control of your choice.
We focus on early in-vivo testing using relevant and time-efficient whole animal models so you can shorten your project timeline. In preclinical stage, our phenotypic screening services help you kickstart your research by testing your hypothesis or conducting proof of concept before you move to a more complex and costly model system.
Using our phenotypic screening services advanced platform, you can quickly and economically test a compound’s ability to extend lifespan and healthspan with large sample sizes of live animals in 2-3 months.
InVivo Biosystems’ longevity platform tracks C. elegans movement throughout their lives. Both lifespan and healthspan are measured every 15 minutes. (Left): Animals’ movement. Color purple: animals are healthy; color yellow: animals are unhealthy; color red: animals are dead. (Right): percent of population alive.
We can identify the pathways that contribute to the observed lifespan extension using RNA-Seq or whole transcriptome sequencing (WTS). For example, we can identify the anti-aging pathways that contribute to the observed lifespan extension from the lifespan analysis.
Data Only
Data Interpretation
Data Customization
We will set up a 30-minute call with you to understand your needs. During this call, we will define the scope of your project, answer your practical questions and help you assess whether our service is a good fit for you.
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After we decide on the scope of the project, we will create a proposal that includes cost and time estimate for each experiment proposed. You will be able to personalize your project plan.
We will send you a final statement of work and payment schedule. Once we receive your first PO, we will start the experiments and give you a defined timeline for your project.
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We will keep you updated every two weeks on the status of your project. At the end of your project, we provide you with a report that includes comprehensive findings and key takeaways.
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Determine if a lead compound ameliorates disease phenotypes or affect important metabolites.
Determine if genes are involved in disease processes and make good targets for further discovery.
Medium throughput screen of compound libraries and biologics (up to BSL2)
Perform acute embryo toxicity testing, targeted hepatotoxicity, neurotoxicity, and cardiotoxicity analysis.
Phenotypic screening focuses on observing the effects of compounds on observable phenotypes, considering the complex interactions within biological systems. In contrast, target-based screening involves designing compounds to interact with specific molecular targets.
Phenotypic screening offers a holistic view of compound effects, allowing for the phenotypic drug discovery with unknown mechanisms of action and identifying novel therapeutic targets. It also considers the complexity of diseases and biological systems, capturing potential multi-target effects that target-based approaches may miss.
Absolutely. Phenotypic screening services are particularly valuable when studying complex diseases. By observing the overall phenotypic changes in diseased cells or tissues, these services can identify compounds that modulate multiple pathways and offer a broader understanding of disease biology.
Assay development in phenotypic screening services involves customizing experimental setups to evaluate the desired phenotypic changes. This includes selecting appropriate cell lines, tissue samples, or model organisms and optimizing assay parameters to ensure sensitivity, reproducibility, and scalability.
Once hits are identified, they undergo comprehensive validation and characterization. This involves further studies to confirm their activity, assess dose-response relationships, explore mechanisms of action, and evaluate potential toxicity and off-target effects. It’s a critical step to ensure the selection of promising candidates for further development.
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Built on a robust portfolio of CRISPR genome editing patents, InVivo Biosystems has established a comprehensive preclinical discovery and development platform. By leveraging alternative models and proprietary methods, we accelerate go-to-market timelines for pharmaceutical companies and beyond.
