Epilepsy Disorder Panel

According to Epilepsy Foundation, epilepsy is the fourth most common neurological disorder and affects people of all ages. Through basic and clinical research, top genes that are mutated in Epilepsy disorder have been identified.

However, it is complex and challenging to select the right mutants to study due to many choices of strains and alleles. In addition, researchers sometimes have doubts that a strain obtained from another source has not lost the mutation or undergone genetic drift.

Our goal is to create a curated, reliable library of strains that are relevant to Epilepsy disorder. We have carefully selected:

  • Strains and genes that are associated with Epilepsy disorder
  • Genetic tests to validate the strains including PCR and sequencing

These sequence validated strains enable researchers to:

  • Screen for drugs with activity against Epilepsy disorder
  • Rapidly identify impactful drugs
  • Test drug compounds on a whole organism
NameHuman GeneWorm Gene HomologueType of transgenicProtein activityWorm Phenotype
EPY STXBP1 Knock-outSTXBP1 - Syntaxin-Binding Protein 1unc-18Lof - entire coding sequence is removedUncoordinated - Pharyngeal pumping frequency reduced
EPY CACNA1A Knock-outCACNA1A - Calcium Channel Voltage-dependent, P/Q-type, alpha-1A subunitunc-2Lof - point mutation resulting in early terminationUncoordinated- Pharyngeal pumping frequency reduced
EPY KCNQ2 Knock-outKCNQ2kqt-1Lof - deletion of region of coding sequencePharyngeal pumping frequency reduced

Key advantages of the Epilepsy Panel

  • Ready-to-screen format enables quicker identification of drug impacts
  • Genetic mutations are validated with sequencing
  • Recommended reference strains selected for their relevance to Epilepsy
  • Consistent number of animals received
  • 3 different packaging to choose from
    • Vial (frozen)
    • Petri plate (room temperature)
    • 96-well plate (room temperature)

Ordering information

PanelFormatQtyCat. No.Price
EPY STXBP1 Knock-out
  • Vial
  • Petri plate
  • 96-well plate
EPY CACNA1A Knock-out
  • Vial
  • Petri plate
  • 96-well plate
EPY KCNQ2 Knock-out
  • Vial
  • Petri plate
  • 96-well plate

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