HomeInVivo Biosystems BlogNewsletterBi-Weekly Newsletter: 4.17.2020

Bi-Weekly Newsletter: 4.17.2020

Find the ideal model for studying your gene of interest

Using CRISPR and other genome editing methods, we can create genetically engineered animal models for better understanding genetic mutations and disease biology discovery. Use this search tool that we developed using public data from Wormbase and Zfin.org to find an ideal model for studying your gene of interest.

Check it out

Featured Findings:

  • Zebrafish acute toxicity study demonstrates concordance with rat fetal embryotoxicity 
    • As the zebrafish is increasingly adopted to test drug toxicity, it is critical to systematically assess the parallels between zebrafish, humans and other model systems. Data determining where phenotype anchors exist, and to what extent, is essential for understanding which areas zebrafish can serve best as a complementary system to mammalian models for facilitating the advancement of drug discovery and environmental monitoring efforts. Read more
  • The Challenge of Getting CRISPR-based Knock-ins to Work in Zebrafish
    • As a community, we appreciate that getting CRISPR based knock-ins to occur efficiently in zebrafish is quite challenging.  We conducted a survey of zebrafish researchers, and all respondents agreed that getting knock-in transgenics is extremely difficult.  Our team has found that success can be higher with well designed reagents and processes. We are approaching an 80% success rate in the knock-in projects we have tried. Yet we need improvements in the process so that everyone can get access to higher efficiency knock-in transgenic production.
      Read more
  • Zebrafish play a pivotal role in new Parkinson's research
    • “Unlike rodent models of [Parkinson’s disease] that take months to run with just a few animals in each treatment group, the zebrafish model of Parkinson’s disease is a high throughput system,” Small-Howard said. “Each experiment takes about a week to complete and each treatment group has a minimum of twenty-five individuals, which makes statistical significance easier to reach quickly".... Read more

P.S.

Need a new playlist to dance out all of coronavirus stress? Check out this COVID-19 Quarantine Dance Party playlist featuring favorites such as Toxic by Brittany Spears to Don't Stand So Close to Me by The Police. At the very least, you can appreciate the irony of the song titles all together.  Start dancing

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