In this issue:
The wMicroTracker instrument can measure the locomotor activity of parasitic nematodes. The conventional way of measuring anthelmintic activity for parasitic nematodes are laborious and low throughput. With the wMicroTracker, the effort and time required on your part is minimized in order to make data collection easier than ever before. The wMicroTracker instrument can be used for library screening and drug discovery in a variety of parasitic nematodes.
In either C. elegans or Zebrafish, a native model organism gene can be replaced by a human gene with the same biological function. Mutations can be introduced into the human gene in order to make a disease variant. Alternatively, the human gene can be expressed in specific tissues or stages of development. Check out how we have quantified behaviors from the humanized C. elegans.
For at least 10 years, C. elegans has been increasingly used as a new, convenient animal model for toxicology, particularly neurological toxicology during development. The model is creating new insights in not only how certain toxins can influence nervous system function, but also is more effective at mapping how these changes can occur over time. The tiny roundworm could finally determine how certain disorders and toxic reactions can have long-term effects, as well as rule out chemicals that may not ultimately have any effect
We are honored to have Dr. Anne Hart of Brown University as our Spring Featured Scientist. Dr. Hart’s research focuses on fundamental problems in neuroscience using tools available in the nematode C. elegans. Dr. Hart is Director of the Brown University Neuroscience Graduate Program and Assistant Chair of the Department of Neuroscience.
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Ask An Expert
Q: How do you overcome the challenge of generating mutant lines with substantial variability in PCR detection of loxP site integration at target loci?
A: The way we get around the variability in PCR detection is with optimized, locus-specific PCR assays; we get around complex on-target mutagenesis at and between loxP target loci with two sequential rounds of injection and screening…Read the full explanation on the blog
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