June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking place in alternative animal models:
C. elegans:
- Kumar DK, Choi SH, Washicosky KJ, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci Transl Med. 2016;8(340):340ra72. doi:10.1126/scitranslmed.aaf1059
- Fang EF, Hou Y, Palikaras K, et al. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease. Nat Neurosci. 2019;22(3):401‐412. doi:10.1038/s41593-018-0332-9
- Griffin EF, Caldwell KA, Caldwell GA. Genetic and Pharmacological Discovery for Alzheimer’s Disease Using Caenorhabditis elegans. ACS Chem Neurosci. 2017;8(12):2596‐2606. doi:10.1021/acschemneuro.7b00361
Zebrafish:
- Saleem, S., & Kannan, R. R. (2018). Zebrafish: an emerging real-time model system to study Alzheimer’s disease and neurospecific drug discovery. Cell death discovery, 4, 45. https://doi.org/10.1038/s41420-018-0109-7
- Newman M, Hin N, Pederson S, Lardelli M. Brain transcriptome analysis of a familial Alzheimer’s disease-like mutation in the zebrafish presenilin 1 gene implies effects on energy production. Mol Brain. 2019;12(1):43. Published 2019 May 3. doi:10.1186/s13041-019-0467-y
- Pu YZ, Liang L, Fu AL, et al. Generation of Alzheimer’s Disease Transgenic Zebrafish Expressing Human APP Mutation Under Control of Zebrafish appb Promotor. Curr Alzheimer Res. 2017;14(6):668‐679. doi:10.2174/1567205013666161201202000
- Koehler D, Williams FE. Utilizing zebrafish and okadaic acid to study Alzheimer’s disease. Neural Regen Res. 2018;13(9):1538‐1541. doi:10.4103/1673-5374.237111
