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Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead

Neurotoxin exposure is implicated in the etiology of neurodegenerative diseases including Parkinson’s disease, Alzheimer’s disease and ALS (amyotrophic lateral sclerosis). Traditionally, vertebrate animals such as rodents and fish have been used for experimental work in neurotoxicology. However, researchers are increasingly turning to invertebrates such as the nematode, C. elegans, for a variety of compelling reasons

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National Epilepsy Week 2019

May 20th-26th 2019 is National Epilepsy Week! National Epilepsy Week is dedicated to educating the broader community on epilepsy, supporting those who suffer from the condition, and general awareness building in regards to epilepsy and potential treatments. NemaMetrix is dedicated to being part of the solution leading to “a world without epilepsy”. Though there are …

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C. elegans showing its weight in neuro-toxicology research

Researching chemicals that may cause damage to the nervous system is very challenging—of the 1,000 known toxic chemicals, only a dozen have been found to be toxic, but many unknowns exist. While mammal models remain the primary selection of research labs looking at the effects of metals and certain organic molecules on the brain—especially the …

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Meet Janis Weeks: A Neuroscientist Turned Global Health Advocate

Dr. Janis Weeks is the first to admit her career arc has been anything but traditional. The neuroscientist turned parasite researcher and global health advocate fell in love with Africa on her first visit in 1996, while teaching in a neuroscience short-course. Since then her connections with the African continent have grown, including becoming a …

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Systems for Improving Diagnostic Yield of Genomic Sequence Analysis

How to better understanding Variants of Uncertain Significance in epilepsy and help find new therapeutic approaches Did you know that 1 in 26 people will experience epilepsy at some point in their lifetime? This statistic is very high, and therefore it is likely many of you have experienced epilepsy or know someone who has. My …

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KCNQ2 epilepsy gene

Functional analysis of variants to aid understanding of children’s epilepsy

Performing sequence analysis on a patient with a suspected genetic disease is becoming a standard of care. However, when a genetic variation is identified as pathogenic in a disease state, clinicians and patients are faced with making difficult care decisions. NemaMetrix has developed a platform that allows us to undertake functional analysis of variants to …

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