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Why Validating Your Plasmids is Key to a Successful Transgenic, and How You Can Do It Too.

Plasmids are a key tool in molecular biology. These circular pieces of DNA, also called “vectors” or “constructs”,  can be engineered to contain large made-to-order stretches of synthetic DNA. We design plasmids when we need to insert large stretches of synthetic DNA into the genome to create a model organism expressing, for instance,  a fluorescent …

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Seventeen Minutes of Science: From Zebrafish to Electric Fish, the Evolution of a PhD Student’s Research

Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook with a new guest each week to talk about how science and biotechnology is woven into their lives for (you guessed it) 17 minutes! This week on 17 Minutes of …

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Seventeen Minutes of Science: What it Takes to Support Zebrafish Research (Episode 8)

Stuck at home with nothing to do during this quarantine? Restless to still be learning and interacting with other scientists? You’re in luck! You can now tune in weekly to our virtual series “Seventeen Minutes of Science”. Every Tuesday at 11am PST / 2pm ET we will go live on Facebook to talk about science …

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6 Key Steps to a Successful Zebrafish Knock-in [Infographic]

Successful zebrafish knock-ins are hard, we are not going to sugar coat it for you, but we at InVivo Biosystems are approaching an 80% success rate in our knock-ins and wanted to share with you what we believe to be the 6 key steps to having a successful knock-in project. Learn more about InVivo Biosystems’ …

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Zebrafish Acute Toxicity Study Demonstrates Concordance with Rat Fetal Embryotoxicity

Summary: As the zebrafish is increasingly adopted to test drug toxicity, it is critical to systematically assess the parallels between zebrafish, humans and other model systems. In this article, we highlight a recent paper that compares toxicity results obtained in zebrafish and rats. The paper concludes that zebrafish are “valuable for predicting mammalian toxic exposure …

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Seventeen Minutes of Science: Modeling Human Diseases in Zebrafish (Episode 4)

Stuck at home with nothing to do during this quarantine? Restless to still be learning and interacting with other scientists? You’re in luck! You can now tune in weekly to our virtual series “Seventeen Minutes of Science”. Every Tuesday at 11am PST/ 2pm ET we will go live on Facebook to talk about science for …

Seventeen Minutes of Science: Modeling Human Diseases in Zebrafish (Episode 4) Read More »

The Challenge of Getting CRISPR-based Knock-ins to Work in Zebrafish

Just the other day, I was talking with a collaborator who told me that they didn’t really believe that knock-ins really worked in zebrafish. Although there have been literature reports for years, the number of labs that struggle and fail with this technique far outweigh the number that find success and publish. So I can …

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