C. elegans

C. elegans CV

C. elegans CV

When you have to apply for a new job, you are asked to provide a resume, CV, and a cover letter. So why then aren’t you asking the same of the model organisms you are using? We put together a fun, yet very informative, C. elegans CV for you to learn more about the small worm and why it makes an ideal model for studying human diseases.

Read More »

worms on drugs featured image

Worms on drugs: How well can C. elegans predict drug toxicity in mammals?

One can kill nematodes by feeding them any number of noxious chemicals, but how effectively can worms predict potential human toxicity of drug leads? Also, given that the dosage is often the difference between a remedy or a poison, how well does the dosage of a drug translate between worms and humans? If worms lack most of the organ systems that would be key targets of drug toxicity, then how do we test toxicity in organ systems that the worms don’t have? We will discuss how InVivo Biosystems addresses these questions when using C. elegans as a model for drug testing.

Read More »

A View From the Bench: Roadblocks and Frustrations When Expectation Meets Reality.

In an effort to create better models for epilepsy, we’ve been working on a grant-funded project to humanize important synaptic machinery by replacing endogenous coding sequences with human coding sequences.  Syntaxin is a key synaptic protein, encoded by the gene STX1A, that helps synaptic vesicles dock, fuse with the membrane, and release neurotransmitters.  Syntaxin has …

A View From the Bench: Roadblocks and Frustrations When Expectation Meets Reality. Read More »

We Used CRISPR to Make 15 Point Mutations in 5 Genes. Here’s What We Learned.

You may or may not know that at InVivo Biosystems, we conduct a lot of grant funded research as well as offering custom models and assays to our clients. Much of our grant activity in the past few years has centered on creating and characterizing disease-associated variants and point mutations. We’ve created collaborations and partnerships …

We Used CRISPR to Make 15 Point Mutations in 5 Genes. Here’s What We Learned. Read More »

Why Validating Your Plasmids is Key to a Successful Transgenic, and How You Can Do It Too.

Plasmids are a key tool in molecular biology. These circular pieces of DNA, also called “vectors” or “constructs”,  can be engineered to contain large made-to-order stretches of synthetic DNA. We design plasmids when we need to insert large stretches of synthetic DNA into the genome to create a model organism expressing, for instance,  a fluorescent …

Why Validating Your Plasmids is Key to a Successful Transgenic, and How You Can Do It Too. Read More »

Precise Knock-outs for Precise Research

Knockouts are the bread and butter of reverse genetic studies. They allow researchers to study the effects of the absence of a particular gene, protein segment, amino acid, or regulatory element, thereby enabling the researcher to determine their function. Many of the classically used and widely available knockout lines researchers rely on are not precise …

Precise Knock-outs for Precise Research Read More »

5 Simple Steps to Improve Your Injection Success

We do injections everyday. While we’ve gotten pretty good at them, they don’t always go as planned. What does it mean if an injection has gone awry, and how can you tell? What does an unsuccessful injection look like? The two videos above illustrate what a successful injection (left) looks like, and what an unsuccessful …

5 Simple Steps to Improve Your Injection Success Read More »

Scroll to Top