Zebrafish Mutagenesis Packages

Zebrafish Point Mutation Service

showcase_point-mutation

The Point Mutation service using zebrafish introduces a small number of nucleotide changes at a target site using CRISPR/Cas9. With this service you can:

  • study a disease-causing mutation
  • humanize a critical amino acid
  • explore the binding site of an enzyme
  • introduce phosphomimetics
  • mutate isoform start sites or make any specific mutation of interest.

Precise Point Mutation of Stxbp1a in Zebrafish

Illustration of a successful precise point mutation of Stxbp1a in Zebrafish. Stxbp1a is a highly conserved zebrafish ortholog of human STXBP1 (87% identity). Using CRISPR/Cas9 technology, we were able to precisely generate a benign patient mutation at the conserved amino acid residue (CCC>CTG, p.P94L).

ZBF-STXBP1_copy

Service Offerings (price reflects academic pricing)

Service PackagePriceEst. Delivery Time
Full Build $26,9559 - 12 months
Verified Clutch $9,3104 - 6 months
Custom Injection Mix (without verification of sgRNA cutting) $995 4-6 weeks
Custom Injection Mix (with verification of sgRNA cutting) $3,259 4 - 8 weeks
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