InVivo Biosystems is a Licensed CRISPR Solutions Provider.
The short generation time and invariant developmental lineage have made C. elegans very useful for understanding, e.g., developmental programs, basic cell biology, neurobiology, and aging.
Over the last decade, the C. elegans transgenic toolbox has expanded considerably, with the addition of a variety of methods to control expression and modify genes with unprecedented resolution.
Highlights of Our C. elegans Services
We specialize in building these tools to help you accomplish your research goal.
Turn it on and off rapidly
Heat-shock promoters allow you to control gene expression through external temperature changes. Cre-recombinase can be placed behind one of these promoters, for activation to occur only when the organism is subjected to heat.
Get the timing right
Introduction of promoters allows you to control when a gene region is expressed. This is appealing for allele floxing in which Cre-recombinase can cause a time-specific or developmental-stage deletion event.
Light it up
Fluorescent tags are often thought of as indicating where a protein is expressed. However, fluorescence also uncovers when a protein is assembled and how much of the protein exists.
Add it all together
Differentially-activated promoters and tags provide you with the most control possible. These options allow control over when expression occurs and where modifications are made.
Using the power of gene replacement, customized animal models can be created using genes from other organisms – even humans. This allows simple animal models to become a platform for disease discovery and compound screening.