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[New Webinar] A Shortcut to Understanding Longevity

Sign up for our upcoming webinar to learn more about our Longevity Platform and how it can benefit you! Title: A Shortcut to Understanding Longevity: A Rapid in vivo Analysis of a Compound’s Effect on Health and Aging Date: Wednesday February 12th, 2020 Time: 11am PST/2pm ET Agenda: Who are we? Healthy Aging: compounds for improving longevity and …

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Worming into Relevance – How C. elegans Can Help us Understand Human Health

Animal testing in the research-based pharmaceutical industry has been reduced in recent years both for ethical and cost reasons. However, it is still a staple when it comes to discovering new compounds directed at improving human health. Recently, we have come across more and more researchers who are looking for the most efficient way to move …

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A New Approach to Anti-Aging Research

Aging has long been viewed as a disease. For decades, the pharmaceutical industry has focused on understanding and discovering drugs that solve specific medical problems. Now, anti-aging startups like Calico, Unity Biotechnology, resTORbio and Celularity are gathering force to take a different approach and leading the way toward a longevity research revolution. The shift towards preventive medicine has …

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Zebrafish modeling for the clinic: Rapid in vivo functional testing of patient variants for clinical applications.

We use the zebrafish (Danio rerio) as an in vivo model to measure the functional effects of patient-derived genetic variation.  In this way, human genetic variants identified in the clinic are quantitatively and qualitatively connected to model animal phenotypes.  As a proof of concept study, we used precision gene editing and transient knockdown approaches targeting stxbp1a – the …

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Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead

“Lead (Pb) is an environmental neurotoxicant, and has been implicated in several neurological disorders of dopaminergic dysfunction; however, the molecular mechanism of its toxicity has yet to be fully understood.” – Akinyemi et al. (2019) Overview Toxicology is the scientific study of the adverse effects of chemical substances or other damaging stimuli (e.g., radiation) on …

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