A New Approach to Anti-Aging Research

Aging has long been viewed as a disease. For decades, the pharmaceutical industry has focused on understanding and discovering drugs that solve specific medical problems. Now, anti-aging startups like Calico, Unity Biotechnology, resTORbio and Celularity are gathering force to take a different approach and leading the way toward a longevity research revolution. The shift towards preventive medicine has …

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Zebrafish modeling for the clinic: Rapid in vivo functional testing of patient variants for clinical applications.

We use the zebrafish (Danio rerio) as an in vivo model to measure the functional effects of patient-derived genetic variation.  In this way, human genetic variants identified in the clinic are quantitatively and qualitatively connected to model animal phenotypes.  As a proof of concept study, we used precision gene editing and transient knockdown approaches targeting stxbp1a – the …

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Where the Lead Leads: Seeking Mechanisms of Action in C. elegans for Neurotoxic Effects of Lead

“Lead (Pb) is an environmental neurotoxicant, and has been implicated in several neurological disorders of dopaminergic dysfunction; however, the molecular mechanism of its toxicity has yet to be fully understood.” – Akinyemi et al. (2019) Overview Toxicology is the scientific study of the adverse effects of chemical substances or other damaging stimuli (e.g., radiation) on …

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Zebrafish and C. elegans in ALS: tightening the bench-to-clinic gap

While advances in molecular imaging, high-throughput screening, genomics and techniques like CRISPR-Cas9 gene editing have dramatically enhanced our understanding of the human body and disease, the pace of advancing new treatments for those diseases has lagged behind significantly. One way to shorten the time between laboratory discoveries and available new drugs is to use animal …

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