KCNQ2 Cures Summit – Patient Family Passion and Involvement

The passion to find answers is inspiring. I had the good fortune to attend the KCNQ2 Cure Summit 2018. Meeting the patient families and seeing their passion to find answers, brings meaning and urgency to the work I have been doing to develop high-throughput drug screening platforms. What can we do to help these families? …

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Featured Scientist: Shawn Lockery (University of Oregon, NemaMetrix)

    My academic research at the University of Oregon concerns the neuronal basis of behavior in one of the smallest brains known to science, that of the nematode C. elegans. This work was founded on developing methodology for recording the tiny electrical signals from individual C. elegans neurons (Figure 1). My contributions to our …

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Worming into Relevance – Human disease models in the C. elegans nematode

The philosopher Friedrich Nietzsche once said: “You have evolved from worm to man, but much within you is still worm.” Genetic diversity in individuals and between species is responsible for bewildering variability and biological niche adaptation of life, yet much of the essential genes involved in disease presentation are highly conserved from yeast to humans. …

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CRISPR/Cas9 off target effects: Hyperactive cutting or media hype?

There has been a lot of media coverage in recent months surrounding CRISPR/Cas9 and the potentially life changing impact the gene-editing technology could have. More recently though, this coverage has focused on the potential for serious consequences in the form of off-target effects. The fear with off-target effects is that CRISPR/Cas9 editing is not as …

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