We discovered that in the absence of cholesterol, NPC mutants display a lower pharyngeal pumping frequency and a longer duration between pumps than control N2 animals. This is the progress we made in our collaborative research project with Perlara and investigation into the lysosomal disorder, Niemann-Pick Type C (NPC).
InVivo Biosystems Blog
Non-mammalian model organisms are typically used in early research to deliver fast answers to a discovery problem. The most popular model organisms in biological and biomedical research are the fruit fly Drosophila melanogaster, the zebrafish and the nematode C. elegans. We provide a comparison of the advantages and limitations of many commonly used model organisms.
NemaMetrix’s ScreenChip collects live-animal, high-throughput C. elegans electropharyngeograms (EPGs), which are an indication of overall organism health for drug development. Read the blog post on BioCoder published by O’Reilly Bio.
Serotonin is well known for being important in the regulation of people’s mood. We found that we can model the serotonin biochemical pathway using a sensitive measure for pharyngeal pumping in C. elegans.
C. elegans’ feeding behavior strongly influences the worm’s aging and longevity. We tested adult worms to quantify how aging affects their feeding behavior. In older adults, pharyngeal pumping was weaker and less regular.
Nemametrix Inc., a life sciences startup that created the innovative ScreenChip System for drug screening, mutant phenotyping, and toxicological assessment, has entered into a marketing partnership with Knudra Transgenics, a genome engineering company specializing in custom built transgenic model organisms for research and drug discovery.
The NemaMetrix ScreenChip platform technology was recognized by the White House as one of the breakthrough life science research technologies. CEO Matt Beaudet spoke with Dr. Robbie Barbero of the US White House Office of Science and Technology Policy, who created a post on the White House website about the promise of new research technologies.