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Kathryn McCormick

Research Spotlight: Alzheimer’s Disease

June is Alzheimer’s & Brain Awareness Month. We wanted to take a few moments to spotlight some of the awe-inspiring research on Alzheimer’s disease taking place in alternative animal models: C. elegans: Kumar DK, Choi SH, Washicosky KJ, et al. Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer’s disease. Sci …

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We Used CRISPR to Make 15 Point Mutations in 5 Genes. Here’s What We Learned.

You may or may not know that at InVivo Biosystems, we conduct a lot of grant funded research as well as offering custom models and assays to our clients. Much of our grant activity in the past few years has centered on creating and characterizing disease-associated variants and point mutations. We’ve created collaborations and partnerships …

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FAVOR Grant

New NIH Grant awarded to InVivo Biosystems to address critical needs in precision medicine research

New NIH Grant awarded to InVivo Biosystems to address critical needs in precision medicine research using the model of C. elegans. The grant, titled “Functional Assessment of Variants in Organisms of Research (FAVOR) – Profiling Canonical Human Genes and their Variants through Disease Model Phenotyping” in the amount of $350,000 is awared by the Nation Human Genome Research Institute (NHGRI).

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Zebrafish Acute Toxicity Study Demonstrates Concordance with Rat Fetal Embryotoxicity

Summary: As the zebrafish is increasingly adopted to test drug toxicity, it is critical to systematically assess the parallels between zebrafish, humans and other model systems. In this article, we highlight a recent paper that compares toxicity results obtained in zebrafish and rats. The paper concludes that zebrafish are “valuable for predicting mammalian toxic exposure …

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The Challenge of Getting CRISPR-based Knock-ins to Work in Zebrafish

Just the other day, I was talking with a collaborator who told me that they didn’t really believe that knock-ins really worked in zebrafish. Although there have been literature reports for years, the number of labs that struggle and fail with this technique far outweigh the number that find success and publish. So I can …

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