HomeAnimal Model

Animal Model

Seventeen Minutes of Science: From Zebrafish to Electric Fish, the Evolution of a PhD Student’s Research

Tune in weekly to our virtual series “Seventeen Minutes of Science” every Tuesday at 11am PST / 2pm ET where we go live on Facebook with a new guest each week to talk about how science and biotechnology is woven into their lives for (you guessed it) 17 minutes! This week on 17 Minutes of …

Seventeen Minutes of Science: From Zebrafish to Electric Fish, the Evolution of a PhD Student’s Research Read More »

Precise Knock-outs for Precise Research

Knockouts are the bread and butter of reverse genetic studies. They allow researchers to study the effects of the absence of a particular gene, protein segment, amino acid, or regulatory element, thereby enabling the researcher to determine their function. Many of the classically used and widely available knockout lines researchers rely on are not precise …

Precise Knock-outs for Precise Research Read More »

5 Simple Steps to Improve Your Injection Success

We do injections everyday. While we’ve gotten pretty good at them, they don’t always go as planned. What does it mean if an injection has gone awry, and how can you tell? What does an unsuccessful injection look like? The two videos above illustrate what a successful injection (left) looks like, and what an unsuccessful …

5 Simple Steps to Improve Your Injection Success Read More »

Seventeen Minutes of Science: The Operational and Emotional Impact of COVID-19 on Biomedical Research (Episode 5)

Stuck at home with nothing to do during this quarantine? Restless to still be learning and interacting with other scientists? You’re in luck! You can now tune in weekly to our virtual series “Seventeen Minutes of Science”. Every Tuesday at 11am PST / 2pm ET we will go live on Facebook to talk about science …

Seventeen Minutes of Science: The Operational and Emotional Impact of COVID-19 on Biomedical Research (Episode 5) Read More »

Zebrafish Acute Toxicity Study Demonstrates Concordance with Rat Fetal Embryotoxicity

Summary: As the zebrafish is increasingly adopted to test drug toxicity, it is critical to systematically assess the parallels between zebrafish, humans and other model systems. In this article, we highlight a recent paper that compares toxicity results obtained in zebrafish and rats. The paper concludes that zebrafish are “valuable for predicting mammalian toxic exposure …

Zebrafish Acute Toxicity Study Demonstrates Concordance with Rat Fetal Embryotoxicity Read More »

zebrafish crispr knock in protocol_workflow

6 things that can go wrong while making your Zebrafish CRISPR Knock-In

With the advent of targeted nucleases like zinc-finger nucleases (ZFNs), TALE nucleases (TALENs), and clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-associated proteins (Cas), zebrafish researchers were able to begin interrogating gene function and regions of interest with a precision that was previously out of reach. With these innovations, researchers could not only disrupt …

6 things that can go wrong while making your Zebrafish CRISPR Knock-In Read More »

Worming into Relevance – How C. elegans Can Help us Understand Human Health

Animal testing in the research-based pharmaceutical industry has been reduced in recent years both for ethical and cost reasons. However, it is still a staple when it comes to discovering new compounds directed at improving human health. Recently, we have come across more and more researchers who are looking for the most efficient way to move …

Worming into Relevance – How C. elegans Can Help us Understand Human Health Read More »

Zebrafish modeling for the clinic: Rapid in vivo functional testing of patient variants for clinical applications.

We use the zebrafish (Danio rerio) as an in vivo model to measure the functional effects of patient-derived genetic variation.  In this way, human genetic variants identified in the clinic are quantitatively and qualitatively connected to model animal phenotypes.  As a proof of concept study, we used precision gene editing and transient knockdown approaches targeting stxbp1a – the …

Zebrafish modeling for the clinic: Rapid in vivo functional testing of patient variants for clinical applications. Read More »

Scroll to Top